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1. WO1991000510 - FLUORESCENCE-BASED OPTICAL SENSOR FOR DETECTION OF LIPID-SOLUBLE ANALYTES

Publication Number WO/1991/000510
Publication Date 10.01.1991
International Application No. PCT/US1990/003406
International Filing Date 15.06.1990
Chapter 2 Demand Filed 09.01.1991
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
G01N 2021/6434
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
6434Optrodes
G01N 21/6428
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
G01N 21/648
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
648using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
Y10T 436/196666
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
19Halogen containing
196666Carbon containing compound [e.g., vinylchloride, etc.]
Y10T 436/204165
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
20Oxygen containing
203332Hydroxyl containing
204165Ethanol
Y10T 436/255
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
25including sample preparation
25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
255including use of a solid sorbent, semipermeable membrane, or liquid extraction
Applicants
  • WASHINGTON TECHNOLOGY CENTER [US/US]; Loew Hall, M.S. FH-10 Seattle, WA 98195, US
  • THOMPSON, Richard, B. [US/US]; US
Inventors
  • THOMPSON, Richard, B.; US
  • YAGER, Paul; US
  • BURGESS, Lloyd, W.; US
  • MERLO, Sabina; US
Agents
  • COOK, Robert, R.; Christensen, O'Connor, Johnson & Kindness 2800 Pacific First Centre 1420 Fifth Avenue Seattle, WA 98101, US
Priority Data
367,50816.06.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLUORESCENCE-BASED OPTICAL SENSOR FOR DETECTION OF LIPID-SOLUBLE ANALYTES
(FR) CAPTEUR OPTIQUE POUR LA DETECTION A BASE DE FLUORESCENCE D'ANALYTES SOLUBLES DANS DES LIPIDES
Abstract
(EN)
A sensor, probe, system and method for detecting the presence of or concentration of lipid-soluble analytes such as anesthetics, which involve the use of fluorophore-containing lipid layers or similar amphiphilic structures as the sensor. The lipid layer is constituted such that it has a phase transition temperature equal to or close to the temperature at which the measurement of the analyte is conducted. Partitioning of a suitable analyte into the lipid layer results in a phase change which is then reflected in a change in a fluorescence characteristic, such as a shift in the wavelength of maximum intensity of fluorescence, of the fluorophore, in proportion to the amount of analyte.
(FR)
Un procédé, un système, une sonde et un capteur permettent de détecter la présence ou la concentration d'analytes solubles dans des lipides, tels que des anesthésiques, au moyen de couches de lipides contenant des fluorophores ou des structures amphiphiles similaires qui servent de capteur. La couche de lipide a une température de transition de phase identique ou similaire à la température à laquelle on mesure l'analyte. Le cloisonnement d'un analyte approprié dans la couche de lipide entraîne un changement de phase qui se traduit en un changement d'un paramètre de fluorescence, tel qu'un décalage de la longueur d'onde de l'intensité maximale de fluorescence du fluorophore proportionnel à la quantité d'analyte.
Also published as
Latest bibliographic data on file with the International Bureau