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1. WO1991000362 - PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS

Publication Number WO/1991/000362
Publication Date 10.01.1991
International Application No. PCT/DE1990/000456
International Filing Date 14.06.1990
IPC
C12P 17/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 41/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
CPC
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 41/005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
003by ester formation, lactone formation or the inverse reactions
005by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Applicants
  • SCHERING AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 170/178 Postfach 65 03 11 D-13342 Berlin, DE
Inventors
  • PETZOLDT, Karl; DE
  • SCHMIECHEN, Ralph; DE
  • HAMP, Kurt; DE
  • GOTTWALD, Matthias; DE
Priority Data
P 39 21 593.828.06.1989DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VERFAHREN ZUR RACEMATTRENNUNG VON 4-ARYL-2-OXO-PYRROLIDIN-3-CARBONSÄURE-ESTERN
(EN) PROCESS FOR THE RACEMIC SEPARATION OF 4-ARYL-2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ESTERS
(FR) PROCEDE DE SEPARATION DES RACEMATES D'ESTERS D'ACIDES 4-ARYL-2-OXO-PYRROLIDIN-3-CARBOXYLIQUES
Abstract
(DE)
Ein enzymatisches Verfahren zur Racemattrennung von 4-Aryl-2-oxo-pyrrolidin-3-carbonsäureestern der allgemeinen Formel (I), worin X eine Kohlenstoff-Kohlenstoffbindung oder ein Sauerstoffatom darstellt, R1 einen gegebenenfalls durch Hydroxygruppen, Oxogruppen und/oder Halogenatome substituierten und/oder Stickstoffatome unterbrochenen Kohlenwasserstoffrest mit maximal 16 Kohlenstoffatomen bedeutet, R2 eine Alkylgruppe mit bis zu 4 Kohlenstoffatomen symbolisiert und R3 eine Alkylgruppe mit maximal 6 Kohlenstoffatomen darstellt, wird beschrieben.
(EN)
Described is an enzyme process for the racemic separation of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters of general formula (I), in which X is a carbon-carbon bond or an oxygen atom; R1 is a hydrocarbon group with up to 16 carbon atoms which may be substituted by hydroxy groups, oxo groups and/or halogen atoms and/or may include nitrogen atoms in the chain; R2 is an alkyl group with up to 4 carbon atoms and R3 is an alkyl group with up to 6 carbon atoms.
(FR)
Un procédé enzymatique permet de séparer les racémates d'esters d'acides 4-aryl-2-oxo-pyrrolidin-3-carboxyliques ayant la formule générale (I), dans laquelle X représente une liaison carbone-carbone ou un atome d'oxygène; R1 représente un résidu hydrocarbure ayant au maximum 16 atomes de carbone, interrompu le cas échéant par des atomes d'azote et/ou substitué par des atomes d'halogène et/ou par des groupes oxo ou hydroxyle, R2 représente un groupe alkyle ayant jusqu'à 4 atomes de carbone et R3 représente un groupe alkyle ayant 6 atomes de carbone au maximum.
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