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1. (WO1991000357) NEW STRAIN WITH FILAMENTOUS FUNGI MUTANTS, PROCESS FOR THE PRODUCTION OF RECOMBINANT PROTEINS USING SAID STRAIN, AND STRAINS AND PROTEINS PRODUCED BY SAID PROCESS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/000357 International Application No.: PCT/FR1990/000479
Publication Date: 10.01.1991 International Filing Date: 28.06.1990
IPC:
C07K 14/195 (2006.01) ,C12N 9/36 (2006.01) ,C12N 9/44 (2006.01) ,C12N 15/65 (2006.01) ,C12N 15/79 (2006.01) ,C12N 15/80 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
36
acting on beta-1, 4 bonds between N-acetylmuramic acid and 2-acetylamino 2-deoxy-D-glucose, e.g. lysozyme
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
44
acting on alpha-1, 6-glucosidic bonds, e.g. isoamylase, pullulanase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
65
using markers
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
80
for fungi
Applicants:
CAYLA [FR/FR]; Centre Commercial de Gros Avenue de Larrieu F-31094 Toulouse Cédex, FR (AllExceptUS)
CALMELS, Thierry [FR/FR]; FR (UsOnly)
DURAND, Henri [FR/FR]; FR (UsOnly)
Inventors:
CALMELS, Thierry; FR
DURAND, Henri; FR
Agent:
WARCOIN, Jacques; Cabinet Regimbeau 26, avenue Kléber F-75116 Paris, FR
Priority Data:
89/0883830.06.1989FR
Title (EN) NEW STRAIN WITH FILAMENTOUS FUNGI MUTANTS, PROCESS FOR THE PRODUCTION OF RECOMBINANT PROTEINS USING SAID STRAIN, AND STRAINS AND PROTEINS PRODUCED BY SAID PROCESS
(FR) NOUVELLE SOUCHE ET SES MUTANTS DE CHAMPIGNONS FILAMENTEUX, PROCEDE DE PRODUCTION DE PROTEINES RECOMBINANTES A L'AIDE DE LADITE SOUCHE ET SOUCHES ET PROTEINES OBTENUES SELON CE PROCEDE
Abstract:
(EN) The invention relates to a process for the production of recombinant protein using fibrous fungi, characterised by the fact that a strain of the genus Tolypocladium, into which a DNA sequence coding for said protein which has been placed under the control of elements guaranteeing the expression of said sequence in said strain, has been introduced, is cultivated on an appropriate medium and by the fact that said protein is recovered. The invention also relates to the proteins and strains obtained by putting said process into effect.
(FR) La présente invention se rapporte à un procédé de production de protéine recombinante à l'aide de champignons filamenteux, caractérisé en ce qu'on cultive sur un milieu approprié une souche de genre Tolypocladium dans laquelle on a introduit une séquence d'ADN codant pour ladite protéine placée sous le contrôle d'éléments assurant l'expression de ladite séquence dans ladite souche et en ce qu'on récupère ladite protéine. La présente invention concerne également les protéines et les souches obtenues par la mise en ÷uvre dudit procédé.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP0433431FR2649120