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1. WO1991000352 - PESTIVIRUS NUCLEOTIDE SEQUENCES AND POLYPEPTIDES

Publication Number WO/1991/000352
Publication Date 10.01.1991
International Application No. PCT/NL1990/000092
International Filing Date 29.06.1990
Chapter 2 Demand Filed 25.01.1991
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2267/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
02Animal zootechnically ameliorated
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 15/8509
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
8509for producing genetically modified animals, e.g. transgenic
C12N 2770/24122
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24111Flavivirus, e.g. yellow fever virus, dengue, JEV
24122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • CENTRAAL DIERGENEESKUNDIG INSTITUUT [NL/NL]; Houtribweg 39 NL-8221 RA Lelystad, NL (AllExceptUS)
  • MOORMANN, Robertus, Jacobus, Maria [NL/NL]; NL (UsOnly)
  • WENSVOORT, Gert [NL/NL]; NL (UsOnly)
Inventors
  • MOORMANN, Robertus, Jacobus, Maria; NL
  • WENSVOORT, Gert; NL
Agents
  • DE BRUIJN, Leendert, C. ; Nederlandsch Octrooibureau Scheveningseweg 82 P.O. Box 29720 NL-2502 LS The Hague, NL
Priority Data
890165129.06.1989NL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PESTIVIRUS NUCLEOTIDE SEQUENCES AND POLYPEPTIDES
(FR) SEQUENCES DE NUCLEOTIDES ET POLYPEPTIDES CONTRE LE PESTIVIRUS
Abstract
(EN)
A method of protecting a subject, in particular a domestic animal, against a microbial infection comprises the use of a combination of a nucleotide sequence coding for an antigen related to the infection and a stop transfer nucleotide sequence. A method of constructing a transgenic animal which is resistant to the infectious organism comprises incorporating a nucleotide sequence related to the infection in the genome of the animal. The method is especially useful for providing protection against a pestivirus infections such as hog cholera (swine fever). Also provided are nucleotide sequences and vector constructs thereof, and polypeptides useful for producing vaccines and for diagnosis. A diagnostic method is given which differentiates between infected animals and vaccinated animals.
(FR)
Un procédé servant à protéger un sujet, en particulier un animal domestique, contre une infection microbienne comprend l'utilisation d'une combinaison d'une séquence de nucléotides codant pour un antigène apparenté à l'infection et d'une séquence de nucléotides stoppant le transfert. Un procédé de production d'un animal transgénique qui est résistant à l'organisme infectieux comprend l'incorporation au génome de l'animal d'une séquence de nucléotides apparentée à l'infection. Le procédé est particulièrement utile à la protection contre une infection pestivirale telle que la peste porcine. On décrit également des séquences de nucléotides et des constructions vectorielles de celles-ci, ainsi que des polypeptides utiles à la production des vaccins et au diagnostic. Un procédé diagnostic est prévu qui fait une différenciation entre les animaux infectés et les animaux vaccinés.
Also published as
RO149030
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