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1. WO1991000291 - SERPIN VARIANTS

Publication Number WO/1991/000291
Publication Date 10.01.1991
International Application No. PCT/EP1990/001026
International Filing Date 23.06.1990
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/57 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
C07K 14/81 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
CPC
A61K 38/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
C07K 14/8128
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81Protease inhibitors
8107Endopeptidase (E.C. 3.4.21-99) inhibitors
811Serine protease (E.C. 3.4.21) inhibitors
8121Serpins
8128Antithrombin III
Applicants
  • AKZO N.V. [NL/NL]; Velperweg 76 NL-6824 BM Arnhem, NL (AllExceptUS)
  • DIJKEMA, Reinder [NL/NL]; NL (UsOnly)
  • VISSER, Arie [NL/NL]; NL (UsOnly)
Inventors
  • DIJKEMA, Reinder; NL
  • VISSER, Arie; NL
Agents
  • HERMANS, Franciscus, Guilielmus, Maria; Postbus 20 NL-5340 BH Oss, NL
Priority Data
89201675.926.06.1989EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SERPIN VARIANTS
(FR) VARIANTES DE SERPINE
Abstract
(EN)
Modified antithrombin III variants are developed which contain amino acid substitutions in the region comprising amino acids 384-396. In this region one or more amino acids are replaced by the corresponding amino acid(s) grouped around the factor Xa cleavage site in factor II related to the formation of meizothrombin. These amino acid substitutions result in altered heparin-dependent inhibitory effect of the modified antithrombin III vis-à-vis the factors IIa and Xa, respectively.
(FR)
On a développé des variantes d'antithrombine III modifiée, contenant des substitutions d'acide aminé dans la région comprenant les acides aminés 384 à 394. Dans cette région, on a remplacé un ou plusieurs acides aminés par le ou les acides aminés correspondants groupés autour du site de clivage du facteur Xa se trouvant dans le facteur II lié à la formation de méizothrombine. Ces substitutions d'acides aminés ont pour résultat de modifier l'effet inhibiteur dépendant de l'héparine de l'antithrombine III modifiée vis-à-vis des facteurs IIa et Xa, respectivement.
Also published as
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