Processing

Please wait...

Settings

Settings

1. WO1991000289 - TARGETED LIPOSOMES AND METHODS FOR LIPOSOME-PROTEIN COUPLING

Publication Number WO/1991/000289
Publication Date 10.01.1991
International Application No. PCT/US1990/003582
International Filing Date 22.06.1990
Chapter 2 Demand Filed 22.01.1991
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07D 207/404 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
34with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Oxygen or sulfur atoms
402,5-Pyrrolidine-diones
404with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
C07D 207/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46with hetero atoms directly attached to the ring nitrogen atom
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/665
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
66the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
665the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
A61K 47/6843
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6843the antibody targeting a material from animals or humans
A61K 47/6898
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6891Pre-targeting systems involving an antibody for targeting specific cells
6897Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
6898using avidin- or biotin-conjugated antibodies
A61K 47/6911
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
A61K 47/6913
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
6913the liposome being modified on its surface by an antibody
Applicants
  • THE LIPOSOME COMPANY, INC. [US/US]; One Research Way Princeton Forrestal Center Princeton, NJ 08540, US
Inventors
  • LOUGHREY, Helen, C.; IE
  • CULLIS, Pieter, R.; CA
  • BALLY, Marcel, B.; CA
  • CHOI, Lewis, S., L.; CA
  • WONG, Kim, F.; CA
Agents
  • BLOOM, Allen; The Liposome Company, Inc. One Research Way Princeton Forrestal Center Princeton, NJ 08540, US
Priority Data
370,65023.06.1989US
412,77926.09.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TARGETED LIPOSOMES AND METHODS FOR LIPOSOME-PROTEIN COUPLING
(FR) LIPOSOMES CIBLES ET PROCEDES D'ACCOUPLEMENT DE LIPOSOMES-PROTEINES
Abstract
(EN)
This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subseuquently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates. The present invention also relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome conjugates of the present invention preferably range in size from about 75 nm to about 200 nm. The liposomes of the invention may have a trans-membrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineoplastic agents, and may be used in diagnostic assays.
(FR)
L'invention concerne un procédé permettant de synthétiser un lipide réactif pur comprenant, par exemple, N-[4-(p-maléimidophényle)-butyryle]phosphatidyléthanolamine (MPB-PE) ainsi que des compositions apparentées. Les compositions de l'invention sont utiles en tant qu'agents d'accouplement, et peuvent être incorporées dans des liposomes et ensuite accouplées à des protéines, des cofacteurs ainsi qu'un certain nombre d'autres molécules. Un procédé d'accouplement préféré est également décrit ainsi que des conjugués de protéines. L'invention concerne également un procédé général de production de conjugué dimensionné de protéines-liposomes présentant des temps de circulation sanguine améliorés. L'invention concerne par ailleurs des compositions de conjugués dimensionnés de protéines-liposomes, produites selon le procédé de l'invention. Les conjugués de protéines-liposomes de l'invention ont une taille située dans une plage allant d'environ 75nm à environ 200nm. Les liposomes de l'invention peuvent avoir un potentiel trans-membrane dans leurs membranes, et peuvent être déshydratés. De plus, la composition peut contenir des agents bioactifs ionisables tels que des agents antinéoplastiques, et peut être utilisée dans des analyses de diagnostics.
Latest bibliographic data on file with the International Bureau