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1. WO1991000265 - INTERCALATING AGENTS

Publication Number WO/1991/000265
Publication Date 10.01.1991
International Application No. PCT/GB1990/001004
International Filing Date 29.06.1990
Chapter 2 Demand Filed 25.01.1991
IPC
C07C 237/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
C07D 211/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
C07D 295/15 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
14substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
145with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
15to an acyclic saturated chain
CPC
C07C 237/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
C07C 2603/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2603Systems containing at least three condensed rings
02Ortho- or ortho- and peri-condensed systems
04containing three rings
22containing only six-membered rings
24Anthracenes; Hydrogenated anthracenes
C07D 211/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
C07D 295/15
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
14substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
145with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
15to an acyclic saturated chain
Applicants
  • CANCER RESEARCH TECHNOLOGY LTD. [GB/GB]; 2 Carlton House Terrace London SW1Y 5AR, GB (AllExceptUS)
  • NEIDLE, Stephen [GB/GB]; GB (UsOnly)
  • JENKINS, Terence, Charles [GB/GB]; GB (UsOnly)
  • AGBANDJE, Mavis [GB/GB]; GB (UsOnly)
Inventors
  • NEIDLE, Stephen; GB
  • JENKINS, Terence, Charles; GB
  • AGBANDJE, Mavis; GB
Agents
  • GOLDIN, Douglas, Michael ; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data
8915028.830.06.1989GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INTERCALATING AGENTS
(FR) AGENTS D'INTERCALATION
Abstract
(EN)
Compounds are disclosed having general formula (I), in which n is 1, 2 or 3; and R1 and R2 are each, independently, an ethyl, hydroxyethyl, or hydroxymethyl group; or R1 and R2, together with the nitrogen atom to which they are attached, form a cyclic group which is a 1-piperidino, 2- or 4-(2-hydroxyethyl)-1-piperidino, 2-hydroxymethyl-1-piperidino, 4-(2-hydroxyethyl)- or 4-methyl-1-piperazino, or 4-morpholino group; or a pharmaceutically acceptable salt thereof. The compounds have utility as anti-cancer agents. A method of preparing the compounds, and pharmaceutical compositions containing the compounds, are also disclosed.
(FR)
L'invention se rapporte à des composés représentés par la formule générale (I); où n est égal à 1, à 2 ou à 3; et R1 et R2 représentent chacun, séparément, un groupe éthyle, hydroxyéthyle ou hydroxyméthyle; ou R1 et R2 forment, conjointement avec l'atome d'azote auquel ils sont liés, un groupe cyclique tel qu'un groupe 1-pipéridino, 2- ou 4-(2-hydroxyéthyl)-1-pipéridino, 2-hydroxyméthyl-1-pipéridino, 4-(2-hydroxyéthyl)-pipérazino ou 4-méthyl-1-pipérazino ou 4-morpholino; ou à un sel pharmaceutiquement acceptable d'un tel composé. Ces composés sont utiles comme agents de lutte contre le cancer. Un procédé de préparation de ces composés ainsi que des compositions pharmaceutiques contenant ces composés sont également décrits.
Also published as
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