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1. WO1991000259 - D-PROPRANOLOL AS A SELECTIVE ADENOSINE ANTAGONIST

Considered void:  07.11.1990
Publication Number WO/1991/000259
Publication Date 10.01.1991
International Application No. PCT/US1990/003728
International Filing Date 02.07.1990
Chapter 2 Demand Filed 02.07.1990
IPC
A61K 31/135 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
CPC
A61K 31/135
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
Applicants
  • THE UNITED STATES OF AMERICA, represented by THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE [US/US]; Washington, DC 20231, US
Inventors
  • KLEIN, David, C.; US
  • NIKODIJEVICH, Olga; YU
Agents
  • OLIFF, James, A. ; Oliff & Berridge P.O. Box 19928 Alexandria, VA 22320, US
Priority Data
373,86330.06.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) D-PROPRANOLOL AS A SELECTIVE ADENOSINE ANTAGONIST
(FR) PROPRANOLOL D COMME ANTAGONISTE SELECTIF DE L'ADENOSINE
Abstract
(EN)
Chemicals are disclosed which are useful for inhibiting the actions of adenosine in mammals, comprising: L-propranolol, or D-propranolol, or alprenolol and derivatives thereof for parenteral or topical administration are disclosed for purposes of achieving desired circulating concentrations in the range of 10 nanograms to 10 milligrams per kilogram. D-Propranolol is of special interest because it is relatively inactive as a $g(b)-adrenergic blocking agent. Specific uses of D-propranolol include the treatment of asthma, chronic obstructive pulmonary disease, A-V node conduction disturbances; apnea of preterm infants, pulmonary hypertension, headaches, migraine, and in attention-deficit disorder. D-Propranolol might also be used as a substitute for xanthines in beverages to produce a feeling of well being, awakeness, awareness and increased performance.
(FR)
Des produits chimiques utiles pour l'inhibition de l'action d'adénosine chez les mamifères comprenant: le propanolol-L ou le propanolol-D, ou l'alprénolol, et leurs dérivés pour l'administration parentérale ou topique sont décrits pour réaliser les concentrations voulues variant de 10 nanogrammes à 10 milligrammes par kilogramme. Le propanolol-D est particulièrement intéressant, car il est relativement inactif comme agent blocant adrénergique $g(b). Des usages spécifiques du propanolol-D comprennent le traitement de l'asthme, les maladies pulmonaires obstructives chroniques, les troubles de la conduction nodale AV, l'apnée des enfants prématurés, l'hypertension pulmonaire, maux de tête, migraine, troubles d'attention déficitaires. Le propanolol peut aussi être utilisé comme un substituant aux xanthines dans les boissons pour produire une sensation de bien-être, d'éveil, prise de conscience et un rendement accru.
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