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1. WO1991000112 - ANTIBODY-LACTATE OXIDASE CONJUGATES

Publication Number WO/1991/000112
Publication Date 10.01.1991
International Application No. PCT/US1990/001056
International Filing Date 22.02.1990
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 47/6815
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
6811the drug being a protein or peptide, e.g. transferrin or bleomycin
6815Enzymes
Applicants
  • BRUNSWICK CORPORATION [US/US]; One Brunswick Plaza Skokie, IL 60077, US
Inventors
  • DUNCAN, John, D.; US
  • WRASIDLO, Wolfgang, J.; US
Agents
  • WALDRON, James, S.; Waldron & Associates 2120 L Street, N.W. Suite 200 Washington, DC 20037, US
Priority Data
374,05030.06.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODY-LACTATE OXIDASE CONJUGATES
(FR) CONJUGUES D'ANTICORPS-OXYDASE DE LACTATE
Abstract
(EN)
Conjugates of antibodies and lactate oxidase, linked together by linker molecules, which are designed for therapeutic purposes. The bacterial lactate oxidase linked to an antibody produces the cytotoxic substance hydrogen peroxide at the site of action as dictated by antibody specificity.
(FR)
L'invention concerne des conjugués d'anticorps et d'oxydase de lactate, liés ensemble par des molécules de liaison, lesquels sont destinés à des utilisations thérapeutiques. L'oxydase de lactate bactérienne liée à un anticorps produit la substance cytotoxique peroxyde d'hydrogène sur le site d'action comme cela est dicté par la spécificité de l'anticorps.
Also published as
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