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1. WO1991000110 - FLUOROCARBON EMULSIONS HAVING SATURATED PHOSPHOLIPID EMULSIFIERS

Publication Number WO/1991/000110
Publication Date 10.01.1991
International Application No. PCT/US1989/002947
International Filing Date 05.07.1989
Chapter 2 Demand Filed 05.02.1991
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 49/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
CPC
A61K 49/0433
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
0433containing an organic halogenated X-ray contrast-enhancing agent
A61K 49/0461
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
0433containing an organic halogenated X-ray contrast-enhancing agent
0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
0461Dispersions, colloids, emulsions or suspensions
A61K 49/0471
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
0433containing an organic halogenated X-ray contrast-enhancing agent
0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
0461Dispersions, colloids, emulsions or suspensions
0471Perflubron, i.e. perfluoroctylbromide, C8F17Br emulsions
A61K 9/0026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0026Blood substitute; Oxygen transporting formulations; Plasma extender
Applicants
  • ALLIANCE PHARMACEUTICAL CORP. [US/US]; 3040 Science Park Road San Diego, CA 92121, US
Inventors
  • LONG, David, M., Jr.; US
Agents
  • SIMPSON, Andrew, H.; Knobbe, Martens, Olson and Bear 620 Newport Center Drive, 16th Floor Newport Beach, CA 92660, US
  • SCHLATTER, Edward, A.; Knobbe, Martens, Olson and Bear 620 Newport Center Drive 16th Floor Newport Beach, CA 92660, US
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLUOROCARBON EMULSIONS HAVING SATURATED PHOSPHOLIPID EMULSIFIERS
(FR) EMULSIONS DE FLUOROCARBONES CONTENANT DES EMULSIFIANTS A BASE DE PHOSPHOLIPIDES SATURES
Abstract
(EN)
A fluorocarbon emulsion having particle size stability comprising a continuous aqueous phase, a fluorocarbon in an amount from 25 % to 125 % weight per volume, and an effective amount of an emulsifying agent comprising a phospholipid with substantially saturated carbon bonds and having a particle size that is stable through heat sterilization, which can be used for delivering oxygen to body tissues or for imaging the human body.
(FR)
L'émulsion de fluorocarbones décrite, dont les particules se caractérisent par une granulométrie stable, comprend une phase aqueuse continue, un fluorocarbone en quantité comprise entre 25 et 125 % en poids par volume, ainsi qu'une quantité efficace d'un agent émulsifiant contenant un phospholipide avec liaisons de carbone essentiellement saturées et se caractérisant par une granulométrie stable lorsqu'il est soumis à stérilisation thermique. Une telle émulsion peut être utilisée pour fournir de l'oxygène aux tissus corporels ou pour la représentation en images du corps humain.
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