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1. WO1991000107 - VACCINES AND VECTORS WITH LIQUID ACTIVE PRINCIPLES CONTAINING AN OIL WHICH CAN BE METABOLISED

Publication Number WO/1991/000107
Publication Date 10.01.1991
International Application No. PCT/FR1990/000485
International Filing Date 29.06.1990
Chapter 2 Demand Filed 25.01.1991
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 47/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
CPC
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Applicants
  • SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES (S.E.P.P.I.C.) [FR/FR]; 75, quai d'Orsay F-75321 Paris Cédex 07, FR (AllExceptUS)
  • BRANCQ, Bernard [FR/FR]; FR (UsOnly)
  • TROUVE, Gérard [FR/FR]; FR (UsOnly)
Inventors
  • BRANCQ, Bernard; FR
  • TROUVE, Gérard; FR
Agents
  • PORTAL, Gérard ; Cabinet Beau de Loménie 55, rue d'Amsterdam F-75008 Paris, FR
Priority Data
89/0891803.07.1989FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) VACCINES AND VECTORS WITH LIQUID ACTIVE PRINCIPLES CONTAINING AN OIL WHICH CAN BE METABOLISED
(FR) VACCINS ET VECTEURS DE PRINCIPES ACTIFS FLUIDES CONTENANT UNE HUILE METABOLISABLE
Abstract
(EN)
The invention relates to an injectable emulsion which can be used as an active principle vaccine or vector with a continuous oily phase having a high tolerance in normal conditions for the injection of a human or an animal characterized by: a viscosity lower than 800 mPa.s at 20°C and consisting of at least: 20 to 90 % of an oily adjuvant which is liquid at 4°C containing at least one or more appropriate and pharmaceutically acceptable emulsifiers, a mixture of any proportion of one or more oils which can be metabolised with one or more oils which cannot be metabolised, and 10 to 80 % of a hydrophilic phase containing the active principles or antigenes.
(FR)
La présente invention concerne une émulsion injectable utilisable comme vaccin ou vecteur de principe actif ayant une phase continue huileuse présentant une bonne tolérance dans les conditions normales d'injection à un homme ou un animal, caractérisée par: une viscosité inférieure à 800 mPa.s à 20°C et constituée d'au moins: 20 à 90 % d'un adjuvant huileux liquide à 4°C contenant au moins un ou plusiers émulgateurs, appropriés et pharmaceutiquement acceptables, un mélange en toute proportion d'une ou plusieurs huiles métabolisables avec une ou plusieurs huiles non métabolisables, 10 à 80 % d'une phase hydrophile contenant les principes actifs ou antigènes.
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