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1. WO1991000106 - INJECTABLE MULTI-PHASE EMULSIONS

Publication Number WO/1991/000106
Publication Date 10.01.1991
International Application No. PCT/FR1990/000484
International Filing Date 29.06.1990
Chapter 2 Demand Filed 25.01.1991
IPC
A61K 9/113 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
113Multiple emulsions, e.g. oil-in-water-in-oil
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
CPC
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 9/113
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
113Multiple emulsions, e.g. oil-in-water-in-oil
Applicants
  • SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES (S.E.P.P.I.C.) [FR/FR]; 75, quai d'Orsay F-75321 Paris Cédex 07, FR (AllExceptUS)
  • BRANCQ, Bernard [FR/FR]; FR (UsOnly)
  • TROUVE, Gérard [FR/FR]; FR (UsOnly)
Inventors
  • BRANCQ, Bernard; FR
  • TROUVE, Gérard; FR
Agents
  • PORTAL, Gérard ; Cabinet Beau de Loménie 55, rue d'Amsterdam F-75008 Paris, FR
Priority Data
89/0891703.07.1989FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) INJECTABLE MULTI-PHASE EMULSIONS
(FR) EMULSIONS MULTIPHASIQUES INJECTABLES
Abstract
(EN)
The invention relates to injectable multi-phase emulsions of the E/H/E/ type which can be used as vaccines, or as vehicles of active principles in veterinary or human medecine, which, for each of their components, are pharmaceutically acceptable, and which are stable for at least 12 months in storage at 4°C, with a viscosity which is lower than 300 mPas. Said emulsions include at least the following components: an oily adjuvant composed of: an oily phase which is non-miscible in water representing 20 to 70 % of the formula; an emulsifier system chosen such that the inversion point of the emulsion obtained be between 25 and 45° and representing 2 to 10° of the formula; an aqueous phase containing the antigenes or the active principles and representing 20 to 78 % of the formula, which is obtained in a single mixing operation.
(FR)
La présente invention concerne des émulsions injectables multiphasiques de type E/H/E/ utilisables comme vaccins, ou véhicules de principes actifs en médecine vétérinaire ou humaine, pharmaceutiquement acceptables pour chacun de leurs composants, stables au moins 12 mois au stockage à 4°C, de viscosité inférieure à 300 mPas et comprenant au moins les constituants suivants: un adjuvant huileux composé de: une phase huileuse immiscible à l'eau représentant 20 à 70 % de la formule, un système émulgateur choisi de façon telle que le point d'inversion de l'émulsion obtenue soit compris entre 25 et 45° et représentant de 2 à 10 % de la formule, une phase aqueuse contenant les antigènes ou les principes actifs et représentant de 20 à 78 % de la formule et obtenue en une seule opération de mélange.
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