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1. (WO1990015806) NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1990/015806 International Application No.: PCT/FI1990/000163
Publication Date: 27.12.1990 International Filing Date: 19.06.1990
Chapter 2 Demand Filed: 13.12.1990
IPC:
C07F 9/40 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
40
Esters thereof
Applicants: POHJALA, Esko[FI/FI]; FI (UsOnly)
NUPPONEN, Heikki[FI/FI]; FI (UsOnly)
VEPSÄLÄINEN, Jouko[FI/FI]; FI (UsOnly)
HUHTAMÄKI OY[FI/FI]; P.O. Box 213 SF-20101 Turku, FI (AllExceptUS)
Inventors: POHJALA, Esko; FI
NUPPONEN, Heikki; FI
VEPSÄLÄINEN, Jouko; FI
Agent: OY JALO ANT-WUORINEN AB; Laivurinrinne 2 A 6 SF-00120 Helsinki, FI
Priority Data:
89303921.06.1989FI
Title (EN) NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES
(FR) NOUVEAUX DERIVES D'ACIDE METHYLENEBISPHOSPHONIQUE
Abstract:
(EN) Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R1, R2, R3 and R4 independently are C1-C22-alkyl, C2-C22-alkenyl, C2-C22-alkynyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, aryl, aralkyl, silyl or hydrogen, whereby in the formula (I) at least one of the groups R1, R2, R3 and R4 is hydrogen and at least one of the groups R1, R2, R3 and R4 is different from hydrogen, Q1 is hydrogen, fluorine, chlorine, bromine or iodine, and Q2 is chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and optically active isomers, of the compounds, as well as the pharmaceutically acceptable salts of the compounds.
(FR) Dérivés nouveaux d'acide bisphosphonique pharmaceutiquement actifs de formule (I) dans laquelle R1, R2, R3 et R4 sont indépendamment alkyle C1-C22, alkényle C2-C22, alkynyle C2-C22, cycloalkyle C3-C10, cycloalkényle C3-C10, aryle, aralkyle, silyle, ou hydrogène; dans la formule (I), au moins un des groupes R1, R2, R3 et R4 est hydrogène et au moins un des groupes R1, R2, R3 et R4 est différent de l'hydrogène, Q1 est hydrogène, fluor, chlore, brome, ou iode, et Q2 est chlore, brome ou iode, y compris les stéréoisomères, tels que les isomères géométriques et les isomères optiquement actifs, des composés, ainsi que les sels pharmaceutiquement acceptables des composés.
Designated States: AU, BG, BR, CA, FI, HU, JP, KP, KR, NO, RO, SU, US
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)