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Machine translation
1. (WO1990014832) IMPROVED INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH BUFFERED METRONIDAZOLE COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1990/014832    International Application No.:    PCT/US1990/003195
Publication Date: 13.12.1990 International Filing Date: 04.06.1990
IPC:
A61K 9/00 (2006.01), A61K 31/415 (2006.01)
Applicants: CURATEK PHARMACEUTICALS LIMITED PARTNERSHIP [US/US]; 1965 Pratt Boulevard, Elk Grove Village, IL 60007 (US)
Inventors: BORGMAN, Robert, J.; (US)
Agent: CEPURITIS, Talivaldis; Dressler, Goldsmith, Shore, Sutker & Milnamow, Ltd., Two Prudential Plaza - Suite 4700, 180 North Stetson Avenue, Chicago, IL 60601 (US)
Priority Data:
362,273 06.06.1989 US
Title (EN) IMPROVED INTRAVAGINAL TREATMENT OF VAGINAL INFECTIONS WITH BUFFERED METRONIDAZOLE COMPOSITIONS
(FR) TRAITEMENT INTRAVAGINAL AMELIORE D'INFECTIONS VAGINALES A L'AIDE DE COMPOSITIONS DE METRONIDAZOLE TAMPONNEES
Abstract: front page image
(EN)A composition and method for treatment of bacterial vaginosis and/or trichomoniasis are disclosed. An afflicted vaginia is treated with a therapeutically effective amount of a buffered metronidazole composition having a pH in the range of about 3 to about 4.25, preferably about 3.75 to about 4.25. A preferred such composition comprises metronidazole, a gelled hydrophobic and water-dispersible polymer, such as a polyacrylic acid polymer having a molecular weight in the range of about 1,250,000 to about 4,000,000 daltons, and an aqueous solvent for the metronidazole.
(FR)L'invention concerne une composition et un procédé de traitement de la vaginite et/ou trichomonase bactériennes. On traite le vagin atteint à l'aide d'une quantité thérapeutiquement efficace d'une composition de métronidazole tamponnée dont le pH est compris entre environ 3 et 4,25, de préférence environ 3,75 et environ 4,25. Une composition préférée comprend du métronidazole, un polymère hydrophobe sous forme de gel et dispersible dans l'eau, tel qu'un polymère d'acide polyacrylique ayant une masse moléculaire comprise entre environ 1 250 000 et environ 4 000 000 daltons, et un solvant aqueux destiné au métronidazole.
Designated States: AU, BB, BG, BR, FI, HU, JP, KP, KR, NO, RO, SU.
Publication Language: English (EN)
Filing Language: English (EN)