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1. WO1990014359 - BIOLOGICALLY ACTIVE POLYPEPTIDES BASED ON TRANSFORMING GROWTH FACTOR-BETA SEQUENCES

Publication Number WO/1990/014359
Publication Date 29.11.1990
International Application No. PCT/US1990/001826
International Filing Date 04.04.1990
Chapter 2 Demand Filed 10.12.1990
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/495 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
495Transforming growth factor (TGF)
C07K 16/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/495
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
495Transforming growth factor [TGF]
C07K 16/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors ; ; against growth regulators
Y10S 514/966
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514Drug, bio-affecting and body treating compositions
966Rectal
Y10S 930/12
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
930Peptide or protein sequence
01Peptide or protein sequence
12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Applicants
  • GENENTECH, INC. [US]/[US]
Inventors
  • BURNIER, John, A.
  • CIANCIOLO, George, J.
Agents
  • HASAK, Janet, E.
  • ARMITAGE, Ian, M.
Priority Data
356,96425.05.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOLOGICALLY ACTIVE POLYPEPTIDES BASED ON TRANSFORMING GROWTH FACTOR-BETA SEQUENCES
(FR) POLYPEPTIDES BIOLOGIQUEMENT ACTIFS A BASE DE SEQUENCES DE FACTEURS DE CROISSANCE DE TRANSFORMATION BETA (TGF-$g(b))
Abstract
(EN)
A polypeptide is provided that excludes (a) a full-length mature TGF-$g(b) molecule or precursor TGF-$g(b) molecule or deletion variants of mature or precursor TGF-$g(b) molecules in which from about 1 to 10 amino acid residues have been deleted, (b) a polypeptide of the sequence: Cys-Val-Arg-Gln-Leu-Tyr-Ile-Asp-Phe-Arg-Lys-Asp-Leu-Gly-Trp-Lys, and (c) a polypeptide of the sequence: Arg-Asn-Leu-Glu-Glu-Asn-Cys-Cys-Val-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Arg-Gln-Asp-Leu, said polypeptide comprising an amino acid sequence that is based on conserved sequences in the family of TGF-$g(b) molecules. Such polypeptides are particularly useful therapeutically as immunosuppressive agents when coupled to carrier proteins or crosslinked to form polymers.
(FR)
L'invention se rapporte à un polypeptide qui exclut: (a) une molécule de TGF-$g(b) mûre ou molécule de TGF-$g(b) précurseur de longueur totale ou des variantes de suppression de molécules de TGF-ß mûres ou précurseurs, dans lesquelles environ un à dix résidus d'acides aminés ont été supprimés; (b) un polypeptide ayant la séquence: Cys-Val-Arg-Gln-Leu-Tyr-Ile-Asp-Phe-Arg-Lys-Asp-Leu-Gly-Trp-Lys; et (c) un polypeptide ayant la séquence: Arg-Asn-Leu-Glu-Glu-Asn-Cys-Cys-Val-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Arg-Gln-Asp-Leu, ce polypeptide comprenant une séquence d'acides aminés fondée sur des séquences conservées de la famille des molécules de TGF-$g(b). De tels polypeptides ont une utilité thérapeutique en particulier comme agents immunosuppresseurs, lorsqu'ils sont couplés à des protéines véhicules ou lorsqu'ils sont réticulés pour former des polymères.
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Latest bibliographic data on file with the International Bureau