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1. WO1990014096 - INSECT REPELLANT

Publication Number WO/1990/014096
Publication Date 29.11.1990
International Application No. PCT/US1990/002725
International Filing Date 22.05.1990
Chapter 2 Demand Filed 21.12.1990
IPC
A01N 25/04 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
02containing liquids as carriers, diluents or solvents
04Dispersions or gels
A01N 25/24 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
24containing ingredients to enhance the sticking of the active ingredients
A01N 25/26 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
26in coated particulate form
A61K 8/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
14Liposomes
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
CPC
A01N 25/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, ; e.g. seed treatment or sequential application;
02containing liquids as carriers, diluents or solvents
04Dispersions, ; emulsions, suspoemulsions, suspension concentrates; or gels
A01N 25/24
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, ; e.g. seed treatment or sequential application;
24containing ingredients to enhance the sticking of the active ingredients
A01N 25/26
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, ; e.g. seed treatment or sequential application;
26in coated particulate form
A61K 8/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
14Liposomes; Vesicles
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61Q 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
17Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
02containing insect repellants
Applicants
  • TECHNOLOGY UNLIMITED, INC. [US]/[US]
Inventors
  • GEHO, W., Blair
  • LAU, John, R.
  • WOODS, Darryl, H.
Agents
  • PYLE, Ray, S.
Priority Data
356,50625.05.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INSECT REPELLANT
(FR) AGENT DE REPULSION D'INSECTES
Abstract
(EN)
A time release dispenser of insect repellant and anchored to the stratum corneum, whereby the repellant cargo is dispensed over a period of time, and resists removal by perspiration, abrasion, or detergent wash. An example is a bipolar lipid membrane formed into liposome configuration, and caused to envelope and partition an organic molecule that normally has a very limited solubility in aqueous media. The organic molecule may be, for example, a mosquito repellant N, N-Diethyl-m-toluamide known by the acronym 'DEET'. Another example is an insecticide or repellant for animals. The prior art liposomal delivery system depends upon forming liposomes in an aqueous media, thereby capturing some of the media in the core volume. In the preferred embodiment this invention, a burden of a substantially water insoluble substance is sequestered in a bipolar lipid bladder, which lipid and burden may be used as such or targeted to a designated site. Preferably, a target molecule, such as pyridinethione, is used to anchor the liposomal structure to the stratum corneum.
(FR)
L'invention concerne un distributeur à libération temporelle d'un agent de répulsion d'insectes ancré sur la couche cornée, l'agent répulsif étant distribué sur une période de temps et résistant à l'élimination par la transpiration, l'abrasion ou le lavage avec un détergent. Un exemple est une membrane bipolaire ayant une configuration de liposome qui enveloppe et cloisonne la molécule organique ayant normalement une solubilité très limitée dans un milieu aqueux. La molécule organique peut être, par exemple, LN-diéthyle-m-toluamide de répulsion des moustiques et connue par l'acronyme 'DEET'. Un autre exemple est un insecticide ou agent répulsif d'animaux. Le système d'apport liposomique de l'art antérieur dépend de la formation des liposomes dans un milieu aqueux, capturant ainsi une partie du milieu dans un volume d'un noyau. Dans le mode préféré de cette invention, une 'charge' ou substance chimique à action biologique consistant en une substance sensiblement insoluble dans l'eau est séquestrée dans une vessie lipide bipolaire, lequel lipide et laquelle charge peuvent être utilisés en tant que tels ou ciblés sur un site désigné. De préférence, une molécule cible telle que la pyridinethione est utilisée pour ancrer la structure liposomique sur la couche cornée.
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