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1. WO1990013650 - A PLASMID DNA CONSTRUCT INCLUDING THE GENE ENCODING A MAMMALIAN BETA-NERVE GROWTH FACTOR

Publication Number WO/1990/013650
Publication Date 15.11.1990
International Application No. PCT/SE1990/000301
International Filing Date 08.05.1990
Chapter 2 Demand Filed 03.12.1990
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/48 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
48Nerve growth factor (NGF)
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
48Nerve growth factor [NGF]
C12N 15/85
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
Applicants
  • LOPE MEDICINE AB [SE]/[SE] (AllExceptUS)
  • OLSON, Lars [SE]/[SE] (UsOnly)
  • PERSSON, Håkan [SE]/[SE] (UsOnly)
  • EBENDAL, Ted [SE]/[SE] (UsOnly)
Inventors
  • OLSON, Lars
  • PERSSON, Håkan
  • EBENDAL, Ted
Agents
  • AWAPATENT AB
Priority Data
8901715-612.05.1989SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A PLASMID DNA CONSTRUCT INCLUDING THE GENE ENCODING A MAMMALIAN BETA-NERVE GROWTH FACTOR
(FR) CONSTRUCTION D'ADN PLASMIDAL COMPRENANT LE GENE CODANT UN FACTEUR DE CROISSANCE BETA-NERVEUX CHEZ LES MAMMIFERES
Abstract
(EN)
A plasmid DNA construct comprising essentially DNA sequences endogenous to mammalian cells excluding DNA sequences of viral origin including the gene encoding a mammalian $g(b)-nerve growth factor ($g(b)-NGF) or an active polypeptide fragment thereof, and DNA sequences necessary for replicating the plasmid in a bacterial cell; and a method for the treatment of neurodegenerative diseases.
(FR)
Sont décrits une construction d'ADN plasmidal comprenant essentiellement des séquences d'ADN endogènes aux cellules mammifères à l'exclusion de séquences d'ADN d'origine virale, qui renferme le gène qui code un facteur de croissance bêta-nerveux ches les mammifères ($g(b)-NGF) ou un fragment polypeptidique actif de celui-ci, et des séquences d'ADN nécessaires à la réplication du plasmide dans une cellule bactérienne; ainsi qu'un procédé pouvant être utilisé dans le traitement de maladies de neurodégénérescence.
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