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1. WO1990013561 - THERAPEUTIC AGENT

Publication Number WO/1990/013561
Publication Date 15.11.1990
International Application No. PCT/EP1990/000647
International Filing Date 27.04.1990
Chapter 2 Demand Filed 31.10.1990
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
C07K 5/065 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
065the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 16/40 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40against enzymes
C12N 9/50 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40against enzymes
C07K 5/06026
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06026the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
C07K 5/06078
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06078and aromatic or cycloaliphatic
C12N 9/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
Applicants
  • THE BOOTS COMPANY PLC [GB]/[GB] (AllExceptUS)
  • BARRETT, Alan, John [GB]/[GB] (UsOnly)
  • BUTTLE, David, John [GB]/[GB] (UsOnly)
  • RICH, Daniel, Hulbert [US]/[US] (UsOnly)
Inventors
  • BARRETT, Alan, John
  • BUTTLE, David, John
  • RICH, Daniel, Hulbert
Agents
  • THACKER, Michael, Anthony
Priority Data
8909836.228.04.1989GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC AGENT
(FR) AGENT THERAPEUTIQUE
Abstract
(EN)
This invention relates to chymopapain, improved pharmaceutical compositions containing chymopapain and to methods of treating damaged, herniated or otherwise abnormal intervertebral mammalian spinal discs which comprise injecting into said discs a solution of the improved composition. The invention further relates to processes for preparing the chymopapain of the invention, to inhibitory peptides and affinity chromatography matrices of use in such processes, and to monospecific antibody preparations raised against chymopapain.
(FR)
Chymopapaïne, composé pharmaceutique amélioré contenant de la chymopapaïne et procédés pour soigner chez les mammifères des disques intervertébraux endommagés, herniés ou frappés d'une autre anomalie, consistant à y injecter une solution dudit composé. L'invention porte également sur des procédés pour préparer ladite chymopapaïne, sur des peptides d'inhibition et sur des matrices de chromatographie par affinité servant à la mise en ÷uvre de ces procédés; elle porte enfin sur des préparations d'anticorps monospécifiques élevés contre la chymopapaïne.
Also published as
FI914995
NO19914206
RO148615
Latest bibliographic data on file with the International Bureau