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1. WO1990013534 - DETECTION OF ENDOTOXIN IN PHARMACEUTICAL PREPARATIONS BY MASS SPECTROMETRY

Publication Number WO/1990/013534
Publication Date 15.11.1990
International Application No. PCT/US1990/002459
International Filing Date 03.05.1990
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/6842
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
Applicants
  • COWENS, J., Wayne [US]/[US]
  • MAIDE, Jeannine, A. [US]/[US]
Inventors
  • COWENS, J., Wayne
  • MAIDE, Jeannine, A.
Agents
  • SCOTT, Anthony, C.
Priority Data
347,48504.05.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DETECTION OF ENDOTOXIN IN PHARMACEUTICAL PREPARATIONS BY MASS SPECTROMETRY
(FR) DETECTION D'ENDOTOXINE DANS DES PREPARATIONS PHARMACEUTIQUES PAR SPECTROMETRIE DE MASSE
Abstract
(EN)
The present invention relates to a method of detection of endotoxin in polypeptide compositions. In particular, this invention contemplates a method for measuring endotoxin by quantitating the amount of a volatile derivatized component of endotoxin, beta-hydroxymyristic acid, present in polypeptide compositions. The present invention can be used for testing the endotoxin content of products which are intended for use in clinical medicine, including those produced by recombinant DNA technology.
(FR)
L'invention concerne un procédé de détection d'endotoxine dans des compositions de polypeptide. En particulier, cette invention concerne un procédé de mesure de l'endotoxine par quantification d'un composant volatile dérivé de l'endotoxine, l'acide bêta-hydroxymyristique, présent dans les compositions de polypeptide. La présente invention peut être utilisée pour déterminer la teneur en endotoxine de produits destinés à être utilisés en médecine clinique, y compris les produits préparés par une technologie d'ADN de recombinaison.
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