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1. WO1990013315 - SEX-ASSOCIATED MEMBRANE PROTEINS AND METHODS FOR INCREASING THE PROBABILITY THAT OFFSPRING WILL BE OF A DESIRED SEX

Publication Number WO/1990/013315
Publication Date 15.11.1990
International Application No. PCT/US1989/002069
International Filing Date 12.05.1989
Chapter 2 Demand Filed 11.12.1990
IPC
A61K 35/52 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
52Sperm; Prostate; Seminal fluid; Leydig cells of testes
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 35/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
52Sperm; Prostate; Seminal fluid; Leydig cells of testes
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
G01N 33/5044
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5044involving specific cell types
Applicants
  • CYTOGAM, INC. [US]/[US]
Inventors
  • SPAULDING, Glenn, F.
Agents
  • HALEY, James, F., Jr.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SEX-ASSOCIATED MEMBRANE PROTEINS AND METHODS FOR INCREASING THE PROBABILITY THAT OFFSPRING WILL BE OF A DESIRED SEX
(FR) PROTEINES MEMBRANAIRES ASSOCIEES AU SEXE ET PROCEDES POUR ACCROITRE LA PROBABILITE QUE LA PROGENITURE SERA D'UN SEXE DESIRE
Abstract
(EN)
A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing a sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
(FR)
Sont décrits un procédé pour trier des cellules vivantes sur la base du contenu de l'ADN, des sous-populations de spermatozoïdes de mammifères enrichies en spermatozoïdes X ou Y, des vésicules membranaires plasmatiques de spermatozoïdes enrichies en chromosome X et Y, des protéines membranaires associées au sexe (SAM), pratiquement pures, des anticorps se liant à des protéines X ou Y SAM, essentiellement dépourvus d'anticorps se liant à des protéines Y ou X SAM respectivement, ou bien à l'antigène H-Y. L'invention décrit également des échantillons de sperme enrichi en spermatozoïdes X ou Y, des procédés pour accroître la probabilité que la descendance sera de sexe masculin ou féminin, consistant à laisser un spermatozoïde provenant d'un échantillon de sperme enrichi fertiliser un ÷uf. Sont aussi décrits des procédés pour accroître la probabilité que la descendance sera de sexe masculin ou féminin, consistant à immuniser une femelle avec des protéines X ou Y SAM, ainsi que des procédés pour diminuer la fertilité, consistant à immuniser une femelle avec des spermatozoïdes X et Y, et des procédés pour accroître la probabilité que la descendance d'un mammifère portera un gène pour un caractère particulier lié aux chromosomes sexuels.
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