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1. WO1990013307 - ORGAN PRESERVATION SOLUTION AND METHOD

Publication Number WO/1990/013307
Publication Date 15.11.1990
International Application No. PCT/US1990/002364
International Filing Date 27.04.1990
Chapter 2 Demand Filed 28.11.1990
IPC
A01N 1/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A61K 31/77 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
765Polymers containing oxygen
77of oxiranes
A61K 33/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
42Phosphorus; Compounds thereof
CPC
A01N 1/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A01N 1/0221
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0205Chemical aspects
021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
0221Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
A61K 31/77
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
765Polymers containing oxygen
77of oxiranes
A61K 33/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
42Phosphorus; Compounds thereof
Applicants
  • WATERS INSTRUMENTS, INC. [US]/[US]
Inventors
  • COLLINS, Geoffrey
  • WICOMB, Winston
Agents
  • HALLER, James, R.
Priority Data
345,12128.04.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ORGAN PRESERVATION SOLUTION AND METHOD
(FR) SOLUTION ET PROCEDE DE CONSERVATION D'ORGANES
Abstract
(EN)
An organ preservation solution, particularly valuable in the preservation of mammalian hearts intended for transplantation, contains, in aqueous solution, at least about 3 % by weight of polypropylene glycol having an average molecular weight of at least about 15,000 daltons and being free of material retained by 10 micron filtration, a buffer buffering the pH of the solution perfusate to a value in the range of about 7.1 to about 7.5, and an impermeant composition for retarding the passage of water across cell membranes of an organ treated with the solution.
(FR)
Une solution de conservation d'organes, présentant un intérêt notamment dans la conservation de c÷urs de mammifères destinés à la transplantation, contient, en solution aqueuse, au moins environ 3 % en poids de polypropylène glycol ayant une masse moléculaire moyenne d'au moins environ 15000 daltons et exempt de matière retenue par filtrage à 10 microns. Ladite solution comprend également un tampon tamponnant le pH du perfusat de la solution à une valeur située dans la plage comprise entre environ 7,1 et environ 7,5, ainsi qu'une composition imperméable destinée à retarder le passage de l'eau à travers les membranes cellulaires d'un organe traité à l'aide de ladite solution.
Also published as
Latest bibliographic data on file with the International Bureau