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1. WO1990013285 - PROCESS FOR PRODUCING SMALL PARTICLES OF BIOLOGICALLY ACTIVE MOLECULES

Publication Number WO/1990/013285
Publication Date 15.11.1990
International Application No. PCT/US1990/002421
International Filing Date 01.05.1990
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
CPC
A61K 9/1688
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1688resulting in pure drug agglomerate optionally containing up to 5% of excipient
A61K 9/1694
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1694resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Applicants
  • ENZYTECH, INC. [US]/[US]
Inventors
  • GOMBOTZ, Wayne, R.
  • HEALY, Michael, S.
  • BROWN, Larry, R.
  • AUER, Henry, E.
Agents
  • PABST, Patrea, L.
Priority Data
345,68401.05.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PRODUCING SMALL PARTICLES OF BIOLOGICALLY ACTIVE MOLECULES
(FR) PROCEDE DE PRODUCTION DE PETITES PARTICULES DE MOLECULES BIOLOGIQUEMENT ACTIVES
Abstract
(EN)
Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95 % of the initial biological activity of the molecules in solution.
(FR)
Des particules de petit diamètre de molécules biologiquement actives sont produites par atomisation de solutions de molécules au travers d'un ajutage dans des gaz liquéfiés très froid qui congèlent immédiatement les gouttelettes atomisées. Les particules congelées obtenues ayant des diamètres de 10 à 90 micromètres environ sont lyophilisées pour produire des particules poreuses en suspension dans un non-solvent pour les molécules, et sont exposées à une énergie ultra-sonique ou homogénéisation pour produire des particules ayant des diamètres compris entre 0,1 et 10 micromètres ayant plus de 70 à 95 % de l'activité biologique initiale des molécules en solution.
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