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1. WO1990012807 - PURIFIED, HIGHLY SPECIFIC ANTIBODIES AGAINST GENE PRODUCTS INCLUDING RETINOBLASTOMA AND METHOD

Publication Number WO/1990/012807
Publication Date 01.11.1990
International Application No. PCT/US1990/002017
International Filing Date 13.04.1990
Chapter 2 Demand Filed 07.11.1990
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
CPC
C07K 14/4736
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4736Retinoblastoma protein
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
Applicants
  • BAYLOR COLLEGE OF MEDICINE [US]/[US]
Inventors
  • XU, Hong-Ji
  • BENEDICT, William, F.
  • HU, Shi-Xue
Agents
  • BOULWARE, Margaret, A.
Priority Data
338,28914.04.1989US
508,05111.04.1990US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PURIFIED, HIGHLY SPECIFIC ANTIBODIES AGAINST GENE PRODUCTS INCLUDING RETINOBLASTOMA AND METHOD
(FR) PROCEDE ET ANTICORPS PURIFIES A SPECIFICITE ELEVEE CONTRE DES PRODUITS GENETIQUES, Y COMPRIS DES RETINOBLASTOMES
Abstract
(EN)
A method of identifying epitopes to gene products, specifically the human retinoblastoma (Rb) gene and the corresponding antigenic polypeptides. The amino acid sequence has a combination of low solubility and high hydrophilicity. Highly specific high-affinity anti-Rb-IgGs have been purified using the techniques of this invention. The anti-Rb-IgGs have been used to immuno-precipitate and produce Western Blot patterns associated with normal and abnormal Rb proteins. The method and products of this invention can be used in various diagnostic procedures.
(FR)
Un procédé permet d'identifier les épitopes de produits génétiques, spécifiquement le gène du rétinoblastome humain (Rb) et les polypeptides antigéniques correspondants. La séquence d'acides aminés présente une combinaison de faible solubilité et d'hydrophilie élevée. On a purifié par les techniques décrites des IgG anti-Rb à affinité et à spécificité élevées. On a utilisé ces IgG anti-Rb afin de précipiter immunologiquement et de produire des schémas de Western Blot associés à des protéines de Rb normales et anormales. Ce procédé et ces produits peuvent être utilisés dans différentes démarches diagnostiques.
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