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1. WO1990012574 - DOPAMINE AGONIST COMPOUNDS

Publication Number WO/1990/012574
Publication Date 01.11.1990
International Application No. PCT/US1989/001747
International Filing Date 25.04.1989
IPC
C07D 221/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02condensed with carbocyclic rings or ring systems
04Ortho- or peri-condensed ring systems
18Ring systems of four or more rings
C07D 491/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02in which the condensed system contains two hetero rings
06Peri-condensed systems
CPC
C07D 221/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
02condensed with carbocyclic rings or ring systems
04Ortho- or peri-condensed ring systems
18Ring systems of four or more rings
C07D 491/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
02in which the condensed system contains two hetero rings
06Peri-condensed systems
Applicants
  • NORTHEASTERN UNIVERSITY [US]/[US]
Inventors
  • NEUMEYER, John, L.
  • RAMSBY, Sten
Agents
  • GAGNEBIN, Charles, L., III
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DOPAMINE AGONIST COMPOUNDS
(FR) COMPOSES AGONISTES DE LA DOPAMINE
Abstract
(EN)
Orally effective dopamine agonist compounds are described including in particular novel aporphine compounds. The compounds have a dioxy group on an aromatic nucleus which is cleaved in vivo to release compounds with two adjacent hydroxy groups on the aromatic nucleus. Also described are novel dopamine agonist aporphine compounds wherein the phenolic hydroxyl group is replaced by amino, bromo or fluoro groups.
(FR)
Sont décrits des composés agonistes de la dopamine efficaces oralement et notamment de nouveaux composés d'aporphine. Ces composés possèdent un groupe dioxy sur un noyau aromatique qui est clivé in-vivo pour libérer des composés présentant deux groupes hydroxy adjacents sur le noyau aromatique. Sont également décrits de nouveaux composés d'aporphine agonistes de la dopamine dans lesquels le groupe hydroxyl phénolique est remplacé par des groupes amino, bromo ou fluoro.
Also published as
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