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1. WO1990012570 - THERAPEUTIC CHOLESTEROL GALLSTONE DISSOLUTION METHOD

Publication Number WO/1990/012570
Publication Date 01.11.1990
International Application No. PCT/US1990/002212
International Filing Date 24.04.1990
IPC
A61B 17/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
A61K 31/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
08acyclic, e.g. paraformaldehyde
A61K 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61M 1/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
CPC
A61B 2017/22084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
22082after introduction of a substance
22084stone- or thrombus-dissolving
A61K 31/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
08acyclic, e.g. paraformaldehyde
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61M 1/0058
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
0058Suction-irrigation systems
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • HOFMANN, Alan, F.
  • SCHTEINGART, Claudio, D.
Agents
  • McCLAIN, James, W.
Priority Data
341,90024.04.1989US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC CHOLESTEROL GALLSTONE DISSOLUTION METHOD
(FR) PROCEDE THERAPEUTIQUE DE DISSOLUTION DE CALCULS BILIAIRES EN CHOLESTEROL
Abstract
(EN)
A method and apparatus are disclosed for treating a patient having cholesterol calculi which involves infusing into the biliary tract of said patient a C5-C6 ester, ether or ketone having a boiling point in the range of 80°-140° C or a mixture thereof in an amount and at a flow rate effective to at least partially dissolve said calculi rapidly. The invention also encompasses dissolving cholesterol calculi by exposing such calculi to contact with effective quantities of those solvent compounds. The apparatus includes a high flow rate catheter pumping system for infusing a gallstone dissolution solvent into the gallbladder of a patient and aspirating the gallstone dissolution solvent from the gallbladder, and a unit measure container of the solvent. The preferred esters, ethers and ketones are n-propyl acetate, isopropyl acetate, ethyl propionate, ethyl isobutyrate, cyclopentanone, 3-pentanone and methyl t-amyl ether. Contact flow rates are sufficiently high to insure fluid turbulence in the biliary tract region surrounding the calculi.
(FR)
Un procédé et un appareil sont utiles pour traiter des patients ayant des calculs en cholestérol. Selon le procédé, on introduit dans les conduits biliaires du patient une quantité de C5-C6 ester, d'ether ou de cétone ayant un point d'ébullition compris entre 80°-140° ou un mélange de ceux-ci, à un débit suffisant pour dissoudre rapidement au moins partiellement ces calculs. L'invention comprend également la dissolution de calculs en cholestérol par exposition de ces calculs à des quantités efficaces de ces composés solvants. L'appareil comprend un système de pompage à cathéter à débit élevé qui permet d'introduire un solvant de calculs biliaires dans la vésicule biliaire d'un patient et d'en aspirer le solvant de calculs biliaires, ainsi qu'un récipient de mesure d'unités de solvant. Les esters, éthers et cétones préférés sont l'acétate de n-propyle, l'acétate d'isopropyle, le propionate d'éthyle, l'isobutyrate d'éthyle, la cyclopentanone, la 3-pentanone et l'éther de méthyle t-amyle. Les débits de contact sont suffisamment élevés pour assurer le tourbillonnement du fluide dans la région des conduits biliaires qui entoure les calculs.
Also published as
NO19910025
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