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Machine translation
1. (WO1990009400) M-CSF MONOCLONAL ANTIBODIES THAT RECOGNIZE A NEUTRALIZING CONFORMATIONAL EPITOPE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1990/009400    International Application No.:    PCT/US1990/000202
Publication Date: 23.08.1990 International Filing Date: 17.01.1990
Chapter 2 Demand Filed:    06.09.1990    
IPC:
C07K 14/53 (2006.01), C07K 16/24 (2006.01)
Applicants: CETUS CORPORATION [US/US]; 1400 Fifty-Third Street, Emeryville, CA 94608 (US)
Inventors: HALENBECK, Robert, F.; (US).
KOTHS, Kirston, E.; (US).
WRIN, Joseph, W.; (US)
Agent: HALLUIN, Albert, P.; Cetus Corporation, 1400 Fifty-Third Street, Emeryville, CA 94608 (US).
GIOTTA, Gregory, J.; Cetus Corporation, 1400 Fifty-Third Street, Emeryville, CA 94608 (US)
Priority Data:
310,042 10.02.1989 US
Title (EN) M-CSF MONOCLONAL ANTIBODIES THAT RECOGNIZE A NEUTRALIZING CONFORMATIONAL EPITOPE
(FR) ANTICORPS MONOCLONAUX DE FACTEUR DE STIMULATION DE COLONIES DE MACROPHAGES (M-CSF) QUI RECONNAISSENT UN EPITOPE DE CONFORMATION NEUTRALISANTE
Abstract: front page image
(EN)Monoclonal antibodies are described, and methods of using the same, that bind to an apparent conformational epitope associated with recombinant or native dimeric M-CSF with concomitant neutralization of biological activity, which monoclonal antibodies are substantially unreactive with biologically inactive forms of M-CSF including monomeric and chemically derivatized dimeric M-CSF.
(FR)On décrit des anticorps monoclonaux, ainsi que des procédés utilisant ceux-ci, qui se lient à un épitope de conformation apparente, associé à un facteur de stimulation de colonies de macrophages (M-CSF) recombinant au dimérique natif, qui neutralise l'activité biologique, lesquels anticoprs monoclonaux sont sensiblement non réactifs avec des formes biologiquement inactives de M-CSF, y compris des M-CSF monomériques ou dimériques chimiquement dérivés.
Designated States: FI, JP, NO.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)