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Machine translation
1. (WO1990009399) NEW NEUROTROPHIC FACTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1990/009399    International Application No.:    PCT/JP1990/000154
Publication Date: 23.08.1990 International Filing Date: 08.02.1990
Chapter 2 Demand Filed:    27.06.1990    
IPC:
C07K 14/475 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 541 (JP) (For All Designated States Except US).
KATO, Taiji [JP/JP]; (JP) (For US Only).
TANAKA, Ryo [JP/JP]; (JP) (For US Only)
Inventors: KATO, Taiji; (JP).
TANAKA, Ryo; (JP)
Agent: OHIE, Kunihisa; Ohie Patent Office, Room 403 Horiguchi Bldg., 2-3, Nihonbashi Ningyocho 2-chome, Chuo-ku, Tokyo 103 (JP)
Priority Data:
1/33630 15.02.1989 JP
Title (EN) NEW NEUROTROPHIC FACTOR
(FR) NOUVEAU FACTEUR NEUROTROPHIQUE
Abstract: front page image
(EN)This invention relates to a new neurotrophic factor (NTF) isolated and purified from the block of neurofibromata obtained from the patients suffering from the von Recklinghausen disease. The NTF has a polypeptide portion of a molecular weight of 3.000 ± 500 and is a substance which is thermally stable and sensitive to trypsin and proteinase K. This substance promotes the extension of axons of the neurons of a cerebral cortex in a culture medium of a concentration of 1 to 50 ng/ml.
(FR)Nouveau facteur neurotrophique (NTF) isolé et purifié à partir du bloc de neurofibromata provenant de patients souffrant de la maladie de von Recklinghausen. Le NTF présente une partie polypeptide de poids moléculaire égal à 3 000 ± 500 et est une substance stable à la chaleur et sensible à la trypsine et à la protéinase K. Cette substance stimule le prolongement des axones des neurones du cortex cérébral dans un milieu de culture à une concentration comprise entre 1 et 50 ng/ml.
Designated States: CA, JP, KR, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)