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1. (WO1990009380) INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1990/009380    International Application No.:    PCT/JP1990/000163
Publication Date: 23.08.1990 International Filing Date: 09.02.1990
IPC:
C07D 403/04 (2006.01), C07D 403/06 (2006.01)
Applicants: OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 9, Kanda-Tsukasacho 2-chome, Chiyoda-ku, Tokyo 101 (JP) (For All Designated States Except US).
TONE, Hitoshi [JP/JP]; (JP) (For US Only).
SATO, Seiji [JP/JP]; (JP) (For US Only).
SATO, Hideaki [JP/JP]; (JP) (For US Only).
TAMURA, Katsumi [JP/JP]; (JP) (For US Only).
TAMADA, Shigeharu [JP/JP]; (JP) (For US Only).
KONDO, Kazumi [JP/JP]; (JP) (For US Only).
KAWAGUCHI, Tomoyuki [JP/JP]; (JP) (For US Only).
NAKANO, Yoshimasa [JP/JP]; (JP) (For US Only).
MURAKAMI, Masahiro [JP/JP]; (JP) (For US Only).
ITO, Yoshihiko [JP/JP]; (JP) (For US Only).
KITA, Yasuyuki [JP/JP]; (JP) (For US Only).
AKAI, Shuji [JP/JP]; (JP) (For US Only).
FUJIOKA, Hiromichi [JP/JP]; (JP) (For US Only).
TAMURA, Yasumitsu [JP/JP]; (JP) (For US Only).
MATOBA, Katsuhide [JP/JP]; (JP) (For US Only).
TANIGUCHI, Youichi [JP/JP]; (JP) (For US Only).
NISHITANI, Shinji [JP/JP]; (JP) (For US Only).
HAYAKAWA, Satoshi [JP/JP]; (JP) (For US Only).
KANEYASU, Toshinori [JP/JP]; (JP) (For US Only)
Inventors: TONE, Hitoshi; (JP).
SATO, Seiji; (JP).
SATO, Hideaki; (JP).
TAMURA, Katsumi; (JP).
TAMADA, Shigeharu; (JP).
KONDO, Kazumi; (JP).
KAWAGUCHI, Tomoyuki; (JP).
NAKANO, Yoshimasa; (JP).
MURAKAMI, Masahiro; (JP).
ITO, Yoshihiko; (JP).
KITA, Yasuyuki; (JP).
AKAI, Shuji; (JP).
FUJIOKA, Hiromichi; (JP).
TAMURA, Yasumitsu; (JP).
MATOBA, Katsuhide; (JP).
TANIGUCHI, Youichi; (JP).
NISHITANI, Shinji; (JP).
HAYAKAWA, Satoshi; (JP).
KANEYASU, Toshinori; (JP)
Agent: ASAMURA, Kiyoshi; Room 331, New Ohtemachi Building, 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 100 (JP)
Priority Data:
1/31579 10.02.1989 JP
1/199771 31.07.1989 JP
1/234978 11.09.1989 JP
2/14551 23.01.1990 JP
Title (EN) INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME
(FR) DERIVES D'INDOLE, LEUR PREPARATION ET MEDICAMENT LES CONTENANT DESTINE A LA PREVENTION ET AU TRAITEMENT DE LA NEPHRITE
Abstract: front page image
(EN)This invention relates to indole derivatives of general formula (1) and salts thereof, a method for preparing same, and applications thereof in the prevention and treatment of nephritis, wherein R represents hydrogen, cyano or one of various other substituents, l is an integer of 1 or 2, R?1¿ represents hydrogen, one of various substituents or a group of formula (2) (wherein A represents a single bond, -CH(OH)-, -CH=, -C(=O)- or alkyl, and R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ each represents one of various substituents), and Z represents hydrogen or a group of formula (2) provided that R?1¿ represents a group of formula (2) when Z represents hydrogen.
(FR)Dérivés d'indole de formule générale (1) et leurs sels, procédé de préparation de ces dérivés, et leurs applications dans la prévention et le traitement de la néphrite. Dans la formule (1), R représente hydrogène, cyano ou un substituant parmi différents autres substituants, 1 est un nombre entier valant 1 ou 2, R?1¿ représente hydrogène, un substituant parmi différents substituants ou un groupe de formule (2) (dans laquelle A représente une liaison simple, -CH(OH)-, -CH=, -C(=O)- ou alkyle, et R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ représentent chacun un substituant parmi différents substituants), et Z représente hydrogène ou un groupe de formule (2) à condition que R?1¿ représente un groupe de formule (2) lorsque Z représente hydrogène.
Designated States: KR, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, LU, NL, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)