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1. (WO1990008770) ISOLATION AND CHARACTERIZATION OF A PLASMA PROTEIN WHICH BINDS TO ACTIVATED C4 OF THE CLASSICAL COMPLEMENT PATHWAY

Pub. No.:    WO/1990/008770    International Application No.:    PCT/US1990/000716
Publication Date: Aug 9, 1990 International Filing Date: Feb 2, 1990
IPC: C07K 14/47
C07K 14/81
Applicants: THE UNITED STATES OF AMERICA, represented by THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE
Inventors: HAMMER, Carl, H.
JACOBS, Ruth, M.
FRANK, Michael, M.
Title: ISOLATION AND CHARACTERIZATION OF A PLASMA PROTEIN WHICH BINDS TO ACTIVATED C4 OF THE CLASSICAL COMPLEMENT PATHWAY
Abstract:
The present invention discloses herein a previously unknown, substantially pure, single chain, plasma protein of approximately 120 kDa (hereinafter 'the 120 kDa protein') which binds to activated C4 and C3 of the classical complement pathway and which inhibits lytic functional activity of the pathway at multible steps (including but not limited C1, C4, C2 and C3 site formation). Quantitative Mancini analysis has identified about 300 νg/ml of this protein in plasma and serum.