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1. WO1990004163 - PROCESS AND DEVICE FOR QUANTITATIVE DETECTION OF OPTICALLY ACTIVE SUBSTANCES

Publication Number WO/1990/004163
Publication Date 19.04.1990
International Application No. PCT/EP1989/001175
International Filing Date 06.10.1989
Chapter 2 Demand Filed 02.04.1990
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
G01N 21/21 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
G01N 21/25 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
CPC
A61B 5/14558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
14558by polarisation
G01N 2021/1751
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
1748Comparative step being essential in the method
1751Constructive features therefore, e.g. using two measurement cells
G01N 21/21
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
21Polarisation-affecting properties
G01N 21/256
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
256Arrangements using two alternating lights and one detector
G01N 2201/0621
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
06Illumination; Optics
062LED's
0621Supply
Applicants
  • SIEMENS-ELEMA AB [SE]/[SE] (SE)
  • SIEMENS AKTIENGESELLSCHAFT [DE]/[DE] (AT, BE, CH, DE, FR, GB, IT, JP, LU, NL, SE)
  • SCHMIDTKE, Gerhard [DE]/[DE] (UsOnly)
  • RIEDEL, Wolfgang [DE]/[DE] (UsOnly)
  • WOLF, Helmut [DE]/[DE] (UsOnly)
Inventors
  • SCHMIDTKE, Gerhard
  • RIEDEL, Wolfgang
  • WOLF, Helmut
Agents
  • SIEMENS-ELEMA AB
Priority Data
P 38 34 160.307.10.1988DE
P 39 08 114.113.03.1989DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VERFAHREN UND VORRICHTUNG ZUR QUANTITATIVEN BESTIMMUNG OPTISCH AKTIVER SUBSTANZEN
(EN) PROCESS AND DEVICE FOR QUANTITATIVE DETECTION OF OPTICALLY ACTIVE SUBSTANCES
(FR) PROCEDE ET DISPOSITIF DE DETECTION QUANTITATIVE DE SUBSTANCES OPTIQUEMENT ACTIVES
Abstract
(DE)
Eine Vorrichtung zur quantitativen Bestimmung optisch aktiver Substanzen verfügt über zwei Lumineszenzdioden (1, 21) mit jeweils einer Kollimatorlinse (3, 23) und einem Polarisationsfilter (5, 25), über eine Küvette (10), die mit Dialysat (11) gefüllt ist, über einen Analysator (33) und einen Detektor (34) mit einer nachgeschalteten Meß- und Auswerteelektronik (36, 37). Das getaktete Licht der Lumineszenzdioden (1, 21) wird durch die Polarisationsfilter (5, 25) linear polarisiert. Die Polarisationsrichtungen sind dabei um wenige Grad verschieden. Die Polarisationsrichtung des Analysators (33) steht im wesentlichen rechtwinklig zu den Polarisationsfiltern (5, 25), so daß die ein optisch nicht drehendes Dialysat (11) durchlaufende Strahlung der beiden Lumineszenzdioden (1, 21) in dem Detektor (34) getaktet das gleiche Photosignal (35) erzeugt. Die Polarisation der durch ein optisch drehendes Dialysat (11) tretenden Strahlung wird dagegen gleichsinnig weitergedreht, so daß der Detektor (34) von den Lumineszenzdioden (1, 21) zwei unterschiedliche Photosignale (35) erhält, aus denen durch Vergleich auf dei Konzentration von optisch aktiven Stoffen geschlossen werden kann. Die Küvette (10) verfügt über eine mit einer Referenzflüssigkeit gefüllte Kammer, durch die die Strahlung der zwei Lumineszenzdioden (1, 21) hindurchtritt. Die Strahlung wird mit einer weiteren Photodiode aufgenommen und für einen automatischen Signalabgleich verglichen.
(EN)
A process for quantitatively detecting optically active substances has two light emitting diodes (1, 21) provided each with a collimating lens (3, 23) and a polarising filter (5, 25), a cell (10) filled with a dialysate (11), an analyser (33) and a detector (34) connected with measurement and evaluation electronics (36, 37). The timed light of the light-emitting diodes (1, 21) is linearly polarized by the polarising filters (5, 25). The directions of polarisation differ by a few degrees. The direction of polarisation of the analyzer (33) is essentially perpendicular to the polarising filters (5, 25), so that the radiation of both light emitting diodes (1, 21) that passes through an optically non-rotating dialysate (11) generates in a timed manner the same photosignal (35) in the detector (34). The polarisation of the radiation that passes through an optically rotating dialysate (11) is further rotated in the same direction, so that the detector (34) receives from the light emitting diodes (1, 21) two different photosignals, from which the concentation of optically active substances can be deduced by comparison. The cell (10) contains a chamber filled with a reference liquid through which passes the radiation of the two light emitting diodes (1, 21). The radiation is recorded by another photodiode and compared for automatic signal compensation purposes.
(FR)
Un dispositif de détection quantitative de substances optiquement actives comprend deux diodes électroluminescentes (1, 21) pourvues chacune d'un objectif collimateur (3, 23) et d'un filtre polarisateur (5, 25), une cuvette (10) remplie d'un dialysat (11), un analyseur (33) et un détecteur (34) auquel sont connectés des éléments électroniques de mesure et d'évaluation (36, 37). La lumière synchronisée des diodes électroluminescentes (1, 21) est linéairement polarisée à travers les filtres polarisateurs (5, 25). Les sens de polarisation diffèrent de quelques degrés. Le sens de polarisation de l'analyseur (33) est essentiellement perpendiculaire aux filtres polarisateurs (5, 25), de sorte que le rayonnement des deux diodes électroluminescentes (1, 21) qui traverse un dialysat (11) exempt de rotation optique génère de manière synchronisée le même photosignal (35) dans le détecteur (34). La polarisation du rayonnement qui traverse un dialysat (11) à rotation optique est par contre mise en rotation dans le même sens, de sorte que le détecteur (34) reçoit des diodes électroluminescentes (1, 21) deux photosignaux différents, à partir desquels on peut déterminer par comparaison la concentation de substances optiquement actives. La cuvette (10) comprend une chambre remplie d'un liquide de référence à travers lequel passe le rayonnement des deux diodes électroluminescentes (1, 21). Le rayonnement est enregistré par une photodiode supplémentaire et comparé à des fins de compensation automatique des signaux.
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