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1. WO1990003972 - DERIVATIVES OF METAL-4 ((PHENYL-4 PIPERAZINYL-1)-2 ETHYL))-5 THIAZOLE

Publication Number WO/1990/003972
Publication Date 19.04.1990
International Application No. PCT/FR1989/000520
International Filing Date 10.10.1989
Chapter 2 Demand Filed 23.03.1990
IPC
C07D 277/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
22with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
28Radicals substituted by nitrogen atoms
CPC
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 7/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
10Antioedematous agents; Diuretics
C07D 277/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
22with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
28Radicals substituted by nitrogen atoms
Applicants
  • INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) [FR]/[FR] (AllExceptUS)
  • HOUZIAUX, Patrick [FR]/[FR] (UsOnly)
  • RIFFAUD, Jean-Pierre [FR]/[FR] (UsOnly)
  • LACOLLE, Jean-Yves [FR]/[FR] (UsOnly)
  • DANREE, Bernard [FR]/[FR] (UsOnly)
Inventors
  • HOUZIAUX, Patrick
  • RIFFAUD, Jean-Pierre
  • LACOLLE, Jean-Yves
  • DANREE, Bernard
Agents
  • HUBERT, Philippe
Priority Data
88/1337511.10.1988FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) DERIVATIVES OF METAL-4 ((PHENYL-4 PIPERAZINYL-1)-2 ETHYL))-5 THIAZOLE
(FR) DERIVES DE METHYL-4 ((PHENYL-4 PIPERAZINYL-1)-2 ETHYL)-5 THIAZOLE
Abstract
(EN)
The present invention relates to new derivatives of methyl-4 [(phenyl-4 piperazinyl-1)-2 ethyl]-5 thiazole, having general formula (I) wherein R is selected amongst a hydrogen atom, an alkyl radical having from 2 to 7 carbon atoms, an aralkyl radical wherein the aryl portion consist preferably in phenyl and of which the alkyl portion has from 1 to 4 carbon atoms, as well as the pharmaceutically acceptable salts of these derivatives. The invention also relates to a method for the preparation of these products and, pharmaceutical compositions containing them. These derivatives find particularly application to the preparation of drugs intended for the treatment of functional dysuries associated with a hyperactivity of the $g(a)-adrenergic sympathic system.
(FR)
La présente invention concerne de nouveaux dérivés du méthyl-4 [(phényl-4 pipérazinyl-1)-2 éthyl]-5 thiazole, de formule générale (I), dans laquelle R est choisi parmi un atome d'hydrogène, un radical alkyle ayant de 2 à 7 atomes de carbone, un radical aralkyle, dans lequel la partie aryle consiste de préférence en phényle et dont la partie alkyle présente de 1 à 4 atomes de carbone, ainsi que les sels pharmaceutiquement acceptables de ces dérivés. Elle concerne également un procédé de préparation de ces produits et des compositions pharmaceutiques les incorporant. Ces dérivés trouvent notamment application pour la préparation de médicaments destinés au traitement des dysuries fonctionnelles liées à une hyperactivité du système sympathique $g(a)-adrénergique.
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