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Machine translation
1. (WO1990002129) BIVALENT LIGANDS EFFECTIVE FOR BLOCKING ACAT ENZYME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1990/002129    International Application No.:    PCT/US1989/002572
Publication Date: 08.03.1990 International Filing Date: 16.06.1989
Chapter 2 Demand Filed:    02.01.1990    
IPC:
C07D 519/00 (2006.01), C07F 7/08 (2006.01)
Applicants: THE UPJOHN COMPANY [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (For All Designated States Except US).
GAMMILL, Ronald, B. [US/US]; (US) (For US Only).
BELL, Frank, P. [CA/US]; (US) (For US Only)
Inventors: GAMMILL, Ronald, B.; (US).
BELL, Frank, P.; (US)
Agent: CORNEGLIO, Donald, L.; Patent Law Department, The Upjohn Company, Kalamazoo, MI 49001 (US).
PERRY, Robert, E.; Gill, Jennings, & Every, 53-64, Chancery Lane, London, WC2A 1HN (GB)
Priority Data:
232,931 16.08.1988 US
Title (EN) BIVALENT LIGANDS EFFECTIVE FOR BLOCKING ACAT ENZYME
(FR) LIGANDS BIVALENTS CAPABLES DE BLOQUER L'ENZYME ACAT
Abstract: front page image
(EN)Bivalent ligand compounds synthesized from a tether composition joining two heterocyclic groups comprising furochromones, furobenzoxazinones, and benzobisdifurans. These compounds show pharmacological activity in blocking ACAT enzymes which are major regulators of cholesterol metabolism. They are useful in the prevention or treatment of the constriction or obstruction of arterial vessels and atherosclerosis.
(FR)Composés de ligands bivalents obtenus par synthèse d'une composition de liaison qui relie deux groupes hétérocycliques consistant en furochromes, furobenzoxazinones et benzobisdifuranes. Lesdits composés ont pour effet pharmacologique de bloquer les enzymes ACAT, principaux régulateurs du métabolisme du cholestérol. Ils sont utiles pour prévenir ou soigner la constriction et l'obstruction des vaisseaux artériels et l'athériosclérose.
Designated States: AU, DK, FI, HU, JP, KR, NO, SU, US.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)