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Machine translation
1. (WO1989012697) METHOD FOR DETECTING ABNORMAL GENES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1989/012697    International Application No.:    PCT/US1989/002731
Publication Date: 28.12.1989 International Filing Date: 21.06.1989
Chapter 2 Demand Filed:    06.02.1990    
IPC:
C12Q 1/68 (2006.01)
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGT [US/US]; ON;, 3755 University May N.E.;, Seattle, WA 98195 (US)
Inventors: ICHINOSE, Akitada; (US)
Agent: MAKI, David, J. @; Seed and Berry, 6300 Colombia Center, Seattle, WA 98104-7092 (US).
BROWN, John, D.; Forrester & Boehmert, Widenmayerstrasse 4, D-8000 Múnchen 22 (DE)
Priority Data:
210,116 22.06.1988 US
Title (EN) METHOD FOR DETECTING ABNORMAL GENES
(FR) PROCEDE DE DETECTION DE GENES ANORMAUX
Abstract: front page image
(EN)Methods for detecting the presence of selected mutations, such as the Thr-601 mutation and the Phe-355 mutation, in the plasminogen of a patient are disclosed. The methods include exposing amplified genomic DNA to a restriction endonuclease capable of differentially cleaving mutant and wild-type plasminogen DNA sequences, and analyzing the exposed DNA to detect the presence or absence of cleavage fragments diagnostic for the selected mutation. Diagnostic kits for the rapid detection of the selected mutation are also disclosed.
(FR)On a mis au point des procédes de détection de la présence de mutations choisies, telles que la mutation Thr-601 et la mutation Phe-355, dans le plasminogène d'un patient. Le procéde consiste à exposer de l'ADN génomique amplifié à une endonucléase de restriction capable de cliver de manière différentielle un mutant et des séquences d'ADN de plasminogène de type sauvage, et à analyser l'ADN exposé afin de détecter la présence ou l'absence de fragments de clivage diagnostiquant la mutation choisie. On a aussi mis au point des kits de diagnostic permettant la détection rapide de la mutation choisie.
Designated States: DK, JP.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)