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1. (WO1989012456) METHOD OF PURIFYING CROSS-LINKED HEMOGLOBIN

Pub. No.:    WO/1989/012456    International Application No.:    PCT/US1989/001489
Publication Date: Dec 28, 1989 International Filing Date: Apr 10, 1989
IPC: C07K 14/805
A61K 38/00
Applicants: BAXTER INTERNATIONAL INC.
Inventors: ESTEP, Timothy, N.
WALDER, Joseph, A.
HAI, Ton-That
Title: METHOD OF PURIFYING CROSS-LINKED HEMOGLOBIN
Abstract:
A method of purifying cross-linked hemoglobin which is mixed with non-cross-linked hemoglobin, which comprises heating the hemoglobin mixture at a temperature of about 60 degrees to 85 degrees C for a time sufficient to cause the precipitation of a substantial amount of the non-cross-linked hemoglobin present. Thereafter, one separates the precipitate thus formed from the cross-linked hemoglobin.