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Machine translation
1. (WO1989012452) FINE-MILLED COLESTIPOL HYDROCHLORIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1989/012452    International Application No.:    PCT/US1989/002187
Publication Date: 28.12.1989 International Filing Date: 24.05.1989
Chapter 2 Demand Filed:    29.01.1990    
IPC:
A61K 31/785 (2006.01), A61K 9/14 (2006.01)
Applicants: THE UPJOHN COMPANY [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (For All Designated States Except US).
MCCURDY, Vincent, E. [US/US]; (US) (For US Only).
SPILMAN, Charles, H. [US/US]; (US) (For US Only)
Inventors: MCCURDY, Vincent, E.; (US).
SPILMAN, Charles, H.; (US)
Agent: COX, Martha, A.; Patent Law Department, The Upjohn Company, Kalamazoo, MI 49001 (US).
PERRY, Robert, E.; Gill Jennings & Every, 53-64 Chancery Lane, London WC2A 1HN (GB)
Priority Data:
211,373 24.06.1988 US
Title (EN) FINE-MILLED COLESTIPOL HYDROCHLORIDE
(FR) CHLORHYDRATE DE COLESTIPOL FINEMENT MOULU
Abstract: front page image
(EN)The present invention provides a novel fine milled form of a known pharmaceutical composition, colestipol hydrochloride. This fine milled form of colestipol hydrochloride yields pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and high dose oral tablets (e.g., 1000 mg tablets). Conventional colestipol hydrochloride was heretoforth available in spherical granules which produced less elegant (gritty) oral suspensions and oral tablets with substantially lower doses of drug (e.g., ca 500 mg).
(FR)L'invention permet d'obtenir une nouvelle forme, finement moulue, d'une composition pharmaceutique connue de chlorhydrate de colestipol. Cette forme finement moulue de chlorhydrate de colestipol fournit des formes de dosage convenant à l'usage pharmaceutique, présentant une activité accrue et comprenant des poudres non graveleuses et des comprimés à dose élevée pour l'administration orale (par exemple, des comprimés de 1000 mg). Le chlorhydrate de colestipol conventionnel existait jusqu'à présent sous la forme de granules sphériques qui fournissaient des suspensions moins adaptées (graveleuses) et des comprimés administrables oralement renfermant des doses médicamenteuses sensiblement moins élevées (par exemple, environ 500 mg).
Designated States: AU, DK, FI, HU, JP, KR, NO, SU.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)