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1. (WO1989012049) DERIVATIVES OF METALLOPORPHYRINES, THEIR PREPARATION, APPLICATION FOR THERAPEUTICAL PURPOSES AND USE IN PREPARING HYBRID MOLECULES

Pub. No.:    WO/1989/012049    International Application No.:    PCT/FR1989/000279
Publication Date: Dec 14, 1989 International Filing Date: Jun 2, 1989
IPC: A61K 41/00
C07D 487/22
C07F 13/00
C07F 15/02
C07F 15/04
C07F 19/00
C07F 3/06
Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS
MEUNIER, Bernard
ETEMAD-MOGHADAM, Guita
DING, Li
CROS, Suzy
Inventors: MEUNIER, Bernard
ETEMAD-MOGHADAM, Guita
DING, Li
CROS, Suzy
Title: DERIVATIVES OF METALLOPORPHYRINES, THEIR PREPARATION, APPLICATION FOR THERAPEUTICAL PURPOSES AND USE IN PREPARING HYBRID MOLECULES
Abstract:
The new derivatives of metalloporphyrines in accordance with the invention are described in formula (I), in which A and B each represent (α) or (β) and Z+ represents N+-R1 or C-N+R1R2R3, R1 being a straight aliphatic group of branched at C1 to C10, and R2 and R3 are each a hydrogen atom or a straight aliphatic group or branched at C1 to C10, R represents an NH2,OH,COOH or -N(R1)3 group or a halogen atom, n and 0 or a whole number between 1 and 10, thereby the corresponding alkylene group may be straight or branched, M represents a transition metal, X- represents the anion of a pharmaceutically acceptable carboxylic acid, m being a whole number between 1 and 5 and Y representing a -O-, -CO- or -CO-NH- bond or radical. Drugs, in particular for anti-tumoral and anti-viral purposes.