WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1989009778) OLIGONUCLEOTIDE CONTAINING 6-THIOGUANINE AT A PREDETERMINED SITE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1989/009778    International Application No.:    PCT/US1989/001531
Publication Date: 19.10.1989 International Filing Date: 12.04.1989
IPC:
C07H 19/20 (2006.01), C07H 21/00 (2006.01)
Applicants: CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY [US/US]; P.O. Box 12137, Research Triangle Park, NC 27709 (US)
Inventors: RICHARDSON, Frank, Charles; (US).
BRONSTEIN, Seymour, Maynard; (US)
Agent: BARBER, Lynn, E.; Olive & Olive, P.O. Box 2049, Durham, NC 27702 (US)
Priority Data:
182,177 15.04.1988 US
Title (EN) OLIGONUCLEOTIDE CONTAINING 6-THIOGUANINE AT A PREDETERMINED SITE
(FR) OLIGONUCLEOTIDE CONTENANT DE LA 6-THIOGUANINE SUR UN SITE PREDETERMINE
Abstract: front page image
(EN)A 6-thioguanine containing phosphoramidite has been synthesized and subsequently utilized in the preparation of an oligonucleotide containing 6-thiodeoxyguanosine. The method includes steps of acylation, alkylation and phosphitylation of 6-thiodeoxyguanosine and incorporation of the resulting phosphoramidite into an oligonucleotide at a specific site. The new oligonucleotide may be used to study the effects of 6-thioguanine on replication, and on alkylation of 6-thioguanine by anticancer agents, and the possible repair of those alkylations.
(FR)On a synthétisé puis utilisé une phosphoramidite contenant de la 6-thioguanine dans la préparation d'un oligonucléotide contenant de la 6-thiodésoxyguanosine. Le procédé comprend les étapes d'acylation, d'alkylation et de phosphitylation de 6-thiodésoxyguanosine, puis d'incorporation de la phosphoramidite résultante dans un oligonucléotide sur un site spécifique. On peut utiliser le nouvel oligonucléotide pour étudier les effets de la 6-thioguanine sur la réplication, et sur l'alkylation de 6-thioguanine par des agents anticancéreux, et l'éventuelle réparation de ces alkylations.
Designated States: JP.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)