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1. (WO1989000696) ANTENATAL SCREENING FOR DOWN'S SYNDROME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000696 International Application No.: PCT/GB1988/000557
Publication Date: 26.01.1989 International Filing Date: 11.07.1988
Chapter 2 Demand Filed: 10.02.1989
IPC:
G01N 33/68 (2006.01) ,G01N 33/74 (2006.01) ,G01N 33/76 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74
involving hormones
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74
involving hormones
76
Human chorionic gonadotropin
Applicants:
3i RESEARCH EXPLOITATION LIMITED [GB/GB]; 91 Waterloo Road London SE1 8XP, GB (AllExceptUS)
WALD, Nicholas, John [GB/GB]; GB (UsOnly)
CUCKLE, Howard, Stephen [GB/GB]; GB (UsOnly)
CANICK, Jacob, Abraham [US/US]; US (UsOnly)
HADDOW, James, Edward [US/US]; US (UsOnly)
Inventors:
WALD, Nicholas, John; GB
CUCKLE, Howard, Stephen; GB
CANICK, Jacob, Abraham; US
HADDOW, James, Edward; US
Agent:
MARCH, Gary, Clifford; Batchellor, Kirk & Eyles 2 Pear Tree Court Farringdon Road London EC1R 0DS, GB
Priority Data:
871615809.07.1987GB
872491323.10.1987GB
Title (EN) ANTENATAL SCREENING FOR DOWN'S SYNDROME
(FR) TEST DISCRIMINATOIRE PRENATAL DU SYNDROME DE DOWN
Abstract:
(EN) An antenatal screening test for risk of Down's Syndrome in a foetus, which is carried out on a maternal blood sample before the beginning of the third trimester of pregnancy, comprises assaying the sample for a metabolite of feto-placental activity which is affected by the presence of Down's Syndrome, and which may be selected from unconjugated oestriol; progesterone; 16-alpha-hydroxy-dehydroepiandrosterone sulphate (16-alpha-hydroxy-DHEAS); and, dehydroepiandrosterone sulphate (DHEAS). The method may also include an additional assay for alpha-fetoprotein and/or human chorionic gonadotrophin.
(FR) Afin de déterminer les risques de présence du syndrome de Down dans un f÷tus, on procède à un test discriminatoire prénatal sur un échantillon de sang maternel avant le début du troisième trimestre de grossesse. Ledit test consiste à analyser l'échantillon pour déterminer la présence d'un métabolite d'activité f÷to-placentaire, qui est affecté par la présence du syndrome de Down et qui peut être sélectionné parmi de l'÷striol non conjugué; de la progestérone; du 16-alpha-hydroxy-déhydroépiandrostérone sulfate (16-alpha-hydroxy-DHEAS); et du déhydroépiandrostérone sulfate (DHEAS). Ledit procédé peut également comporter une analyse supplémentaire pour déterminer la présence d'alpha-f÷toprotéine et/ou de gonadotrophine chorionique humaine.
Designated States: DK, JP, US
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0362294US5605843DKPR 172477