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1. (WO1989000694) IMPROVED TURBIDIMETRIC RATE INHIBITION ASSAY FOR HAPTENS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000694 International Application No.: PCT/US1988/002303
Publication Date: 26.01.1989 International Filing Date: 07.07.1988
IPC:
G01N 33/53 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
COULTER ELECTRONICS, INC. [US/US]; 590 W. 20th Street Hialeah, FL 33010, US
Inventors:
LUCAS, Frank, J.; US
BEDEVIA, Juan; US
SHENKIN, Mark, L.; US
McRAE, Brian, J.; US
CARTER, James, H.; US
CREWS, Harold, R.; US
Agent:
HIBNICK, Gerald, R.; Coulter Electronics, Inc. 590 West 20th Street Hialeah, FL 33010, US
Priority Data:
076,42521.07.1987US
Title (EN) IMPROVED TURBIDIMETRIC RATE INHIBITION ASSAY FOR HAPTENS
(FR) ANALYSE AMELIOREE DE L'INHIBITION DU TAUX TURBIDIMETRIQUE POUR DES HAPTENES
Abstract:
(EN) An improved turbidimetric rate inhibition assay for haptens is disclosed. This assay utilizes both monoclonal antibodies and polyantigenic conjugates in precise proportions in a hapten modulated competitive binding regime, wherein the relative concentration of hapten is inversely proportional to the amount of absorbance of a reaction mixture attributable to a precipitating immunocomplex. The dynamic analytical range and signal to noise ratio of this assay is unique for turbidimetric analysis of haptens. This assay is further unique in the specification for the reagents and in the stability of the reagent, even when fully diluted.
(FR) L'analyse améliorée de l'inhibition du taux turbidimétrique pour des haptènes utilise des anticorps monoclonaux et des conjugués polyantigéniques dans des proportions précises dans un régime de liaison compétitive modulée par des haptènes, la concentration relative d'haptènes étant inversement proportionnelle au degré d'absorption d'un mélange de réaction attribuable à un immunocomplexe de précipitation. La plage analytique dynamique et le rapport signal/bruit de cette analyse sont uniques pour l'analyse turbidimétrique d'haptènes. Cette analyse est également unique par la spécificité des réactifs et la stabilité du réactif même lorsqu'il est entièrement dilué.
Designated States: AU, JP, KR
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0324015AU1988021283