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1. (WO1989000603) A METHOD FOR THE EXPRESSION OF RECOMBINANT GENES UNDER STIMULATION FROM AN INDUCIVELY EXPRESSED ACTIVATOR PROTEIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000603 International Application No.: PCT/EP1988/000640
Publication Date: 26.01.1989 International Filing Date: 15.07.1988
IPC:
C07K 14/61 (2006.01) ,C12N 15/85 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
61
Growth hormone (GH) (Somatotropin)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
INTRACEL CORPORATION [BB/BB]; Cottle Catford & Co. 17 High Street Bridgetown, BB (AllExceptUS)
BROMLEY, Peter [GB/CH]; CH (UsOnly)
DREANO, Michel [FR/FR]; FR (UsOnly)
VOELLMY, Richard [CH/US]; US (UsOnly)
Inventors:
BROMLEY, Peter; CH
DREANO, Michel; FR
VOELLMY, Richard; US
Agent:
DOUSSE, Blasco @; 7, route de Drize CH-1227 Carouge, CH
Priority Data:
87810403.3 (EP)16.07.1987AT
Title (EN) A METHOD FOR THE EXPRESSION OF RECOMBINANT GENES UNDER STIMULATION FROM AN INDUCIVELY EXPRESSED ACTIVATOR PROTEIN
(FR) PROCEDE PERMETTANT L'EXPRESSION PAR STIMULATION DE GENES RECOMBINANTS A PARTIR D'UNE PROTEINE ACTIVATRICE EXPRIMEE PAR INDUCTION
Abstract:
(EN) A DNA system for the stimulated expression of genes of interest. Said genes are placed under the control of an activator stimulated promoter and the gene coding for this activator is driven by an inducible promoter. The hybrid DNA constructions are incorporated in suitable host cells which, after multiplication and optional gene amplification, are stressed, whereby the activator produced continues to bring about expression of said genes of interest for a long period of time after the inducible promoter has returned to rest.
(FR) Le système d'ADN décrit permet l'expression par stimulation de gènes présentant un intérêt. Ces gènes sont placés sous le contrôle d'un promoteur stimulé par un activateur et le gène codant pour cet activateur est activé par un promoteur inductible. Les structures d'ADN hybrides sont incorporées dans des cellules hôtes appropriées, qui, après multiplication et amplification de gènes éventuelle, sont soumises à une contrainte, l'activateur ainsi produit continuant alors à provoquer l'expression desdits gènes pendant une longue période après que le promoteur inductible soit retourné à l'état de repos.
Designated States: AU, DK, JP, NO, US
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19891096AU1988019994