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1. (WO1989000567) BENZOPYRIDAZINONE AND PYRIDOPYRIDAZINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONGESTIVE HEART FAILURE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000567 International Application No.: PCT/US1988/002422
Publication Date: 26.01.1989 International Filing Date: 18.07.1988
Chapter 2 Demand Filed: 12.05.1989
IPC:
C07D 471/04 (2006.01) ,C07D 521/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
521
Heterocyclic compounds containing unspecified hetero rings
Applicants:
RORER INTERNATIONAL (OVERSEAS) INC. [US/US]; P.O. Box 145 Lewes, DE 19958, US
Inventors:
FAITH, William, C.; US
CAMPBELL, Henry, F.; US
KUHLA, Donald, E.; US
STUDT, William, L.; US
BARNES, James, L.; US
Agent:
NICHOLSON, James, A. @; Rorer Group Inc. 500 Virginia Drive, Bldg. #2 Fort Washington, PA 19034, US
BARRON, Alexis; Synnestvedt & Lechner 1101 Market Street Suite 2600 Philadelphia, PA 19107, US
Priority Data:
076,46122.07.1987US
Title (EN) BENZOPYRIDAZINONE AND PYRIDOPYRIDAZINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONGESTIVE HEART FAILURE
(FR) COMPOSES DE BENZOPYRIDAZINONE ET DE PYRIDOPYRIDAZINONE ET LEUR UTILISATION DANS LE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE CONGESTIVE
Abstract:
(EN) This invention relates to imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds of formula (I), wherein A is CH or N and not more than one of W, X, Y and Z is a N atom; Rn is hydrogen, alkyl, aralkyl, acyl, carbalkoxy, carbamyl, carbalkoxyalkyl, hydroxyalkyl, alkoxyalkyl or amidino; or a pharmaceutically acceptable salt thereof, which possess valuable pharmaceutical preparations, e.g., increasing cardiotonic contractility. Uses of said compounds include methods for increasing cardiac contractility and for the treatment of congestive heart failure, and pharmaceutical compositions and the same methods for the preparation thereof.
(FR) Composés de benzopyridazinone et de pyridopyridazinone d'imidazolylphényle et de 1,2,4-triazolylphényle de formule (I) dans laquelle A représente CH ou N et parmi W, X, Y et Z, un de ces éléments au plus représente un atome N; Rn représente de l'hydrogène, de l'alkyle, de l'aralkyle, de l'acyle, du carbalkoxy, du carbanyle, du carbalkoxyalkyle, de l'hydroxyalkyle, de l'alkoxyalkyle ou de l'amidine; ou un de leurs sels pharmaceutiquement acceptable, permettant d'obtenir des préparations pharmaceutiques de grande valeur, par exemple augmentant la contractilité cardiotonique. Les utilisations desdits composés comprennent des procédés permettant d'augmenter la contractilité cardiaque ainsi que le traitement de l'insuffisance cardiaque congestive, des compositions pharmaceutiques et les mêmes procédés pour leur préparation.
Designated States: AU, JP
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1988021359