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1. (WO1989000197) IMPROVED PROCESSES FOR THE TREATMENT OF VASCULAR DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000197 International Application No.: PCT/US1988/002175
Publication Date: 12.01.1989 International Filing Date: 27.06.1988
Chapter 2 Demand Filed: 30.01.1989
IPC:
C12N 9/72 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
72
Urokinase
Applicants:
GENENTECH, INC. [US/US]; 460 Point San Bruno Boulevard South San Francisco, CA 94080, US
Inventors:
HIGGINS, Deborah, L.; US
HOLMES, William, E.; US
HOTCHKISS, Adair, J.; US
Agent:
DREGER, Walter, H. @; Genentech, Inc. Legal Department 460 Point San Bruno Boulevard South San Francisco, CA 94080, US
ARMITAGE, Ian; Mewburn Ellis & Co. 2/3 Cursitor Street London EC4A 1BQ, GB
Priority Data:
068,44830.06.1987US
170,97021.03.1988US
188,23729.04.1988US
Title (EN) IMPROVED PROCESSES FOR THE TREATMENT OF VASCULAR DISEASE
(FR) PROCEDES AMELIORES PERMETTANT LE TRAITEMENT DE MALADIES VASCULAIRES
Abstract:
(EN) Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-life of natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.
(FR) Procédés améliorés permettant de préparer des variantes de protéines de t-PA (activateur plasminogène de tissu) humain présentant des propriétés pharmacocinétiques par rapport au t-PA naturel. Une illustration d'une telle variante, exempte d'acides aminés correspondants aux acides aminés allant de 1 à 44 du t-PA, présente une moitié de vie du plasma supérieure à environ 15 fois la moitié de vie du plasma du t-PA naturel, ainsi qu'une vitesse d'élimination inférieure à environ 1/10 de la vitesse d'élimination du t-PA naturel. Sont également décrits des procédés améliorés permettant de traiter des maladies vasculaires mettant en ÷uvre des compositions pharmaceutiques renfermant des quantités thérapeutiquement efficaces desdites variantes de t-PA avec des diluants ou des excipients pharmaceutiquement acceptables.
Designated States: AU, DK, JP
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0365597AU1988020795DKPR 175369