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1. (WO1989000191) NOVEL THROMBOLYTIC PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000191 International Application No.: PCT/US1988/002263
Publication Date: 12.01.1989 International Filing Date: 06.07.1988
Chapter 2 Demand Filed: 21.02.1989
IPC:
C12N 9/72 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
72
Urokinase
Applicants:
GENETICS INSTITUTE, INC. [US/US]; 87 CambridgePark Drive Cambridge, MA 02140, US
Inventors:
LARSEN, Glenn, R.; US
AHERN, Tim; US
LANGER-SAFER, Pennina; US
Agent:
BERSTEIN, David, L.; Genetics Institute, Inc. 87 CambridgePark Drive Cambridge, Ma 02140, US
Priority Data:
070,01206.07.1987US
184,12120.04.1988US
Title (EN) NOVEL THROMBOLYTIC PROTEINS
(FR) NOUVELLES PROTEINES THROMBOLYTIQUES
Abstract:
(EN) Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification of the tPA peptide sequence. Methods for making these proteins are disclosed as are therapeutic compositions containing same.
(FR) Sont décrites des protéines thrombolytiques ayant une activité tissulaire de type plasminogène. Les protéines sont caractérisées par la modification de la séquence du peptide tPA. Des procédés de fabrication de ces protéines sont décrits comme le sont des compositions thérapeutiques les contenant.
Designated States: AU, DK, FI, HU, JP, KR, NO
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0394261AU1988020817