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1. (WO1989000161) MALIC ACID DERIVATIVE CONTAINING RENIN INHIBITING PEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000161 International Application No.: PCT/US1988/001535
Publication Date: 12.01.1989 International Filing Date: 13.05.1988
Chapter 2 Demand Filed: 30.01.1989
IPC:
C07D 233/54 (2006.01) ,C07D 401/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
THE UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001, US (AllExceptUS)
THAISRIVONGS, Suvit [TH/US]; US (UsOnly)
Inventors:
THAISRIVONGS, Suvit; US
Agent:
WILLIAMS, Sidney, B., Jr.; Patent Law Department The Upjohn Company Kalamazoo, MI 49001, US
PERRY, Robert, E.; Gill Jennings & Every 53-64 Chancery Lane London WC2A 1HN, GB
Priority Data:
068,09529.06.1987US
Title (EN) MALIC ACID DERIVATIVE CONTAINING RENIN INHIBITING PEPTIDES
(FR) DERIVE D'ACIDE MALIQUE CONTENANT DES PEPTIDES INHIBANT LA RENINE
Abstract:
(EN) The present invention provides novel renin-inhibiting peptides of the formula Z-C(O)-CH(OH)-CH(CH2R1)-C(O)-N(R2)-CH(CH2R3)-C(O)-NH-CH(CH2R4)-X-C(R5)(R2)-C(O)-Y-Z containing malic acid derivatives. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension and other related diseases.
(FR) Nouveaux peptides inhibant la rénine, de formule Z-C(O)-CH(OH)-CH(CH2R1)-C(O)-N(R2)-CH(CH2R3)-C(O)-NH-CH(CH2R4)-X-C(R5)(R2)-C(O)-Y-Z, contenant des dérivés d'acide malique. De tels inhibiteurs sont utiles au diagnostic et à la régulation de l'hypertension subordonnée à la rénine, ainsi que d'autres maladies apparentées.
Designated States: AU, DK, FI, JP, KR, NO
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0366669KR1019890701579AU1988017805