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1. (WO1989000159) DERIVATIVES OF CYCLIC AMINO ACIDS, THEIR SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000159 International Application No.: PCT/HU1988/000047
Publication Date: 12.01.1989 International Filing Date: 01.07.1988
Chapter 2 Demand Filed: 18.01.1989
IPC:
C07D 207/16 (2006.01) ,C07D 277/06 (2006.01) ,C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
06
with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
RICHTER GEDEON VEGYÉSZETI GYÁR RT [HU/HU]; Gyömro^"i út 19-21 H-1103 Budapest, HU (AllExceptUS)
DOBAY, László [HU/HU]; HU (UsOnly)
FISCHER, János [HU/HU]; HU (UsOnly)
EZER, Elemér [HU/HU]; HU (UsOnly)
MATUZ, Judit [HU/HU]; HU (UsOnly)
SZPORNY, László [HU/HU]; HU (UsOnly)
SÁGHY, Katalin [HU/HU]; HU (UsOnly)
Inventors:
DOBAY, László; HU
FISCHER, János; HU
EZER, Elemér; HU
MATUZ, Judit; HU
SZPORNY, László; HU
SÁGHY, Katalin; HU
Agent:
PATENTBUREAU DANUBIA; P.O. Box 198 H-1368 Budapest, HU
Priority Data:
3011/8703.07.1987HU
Title (EN) DERIVATIVES OF CYCLIC AMINO ACIDS, THEIR SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME
(FR) DERIVES D'ACIDES AMINES CYCLIQUES, LEURS SELS, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR PROCEDE DE PREPARATION
Abstract:
(EN) The present invention relates to novel compounds of general formula (I), wherein R stands for hydrogen or halogen or a C1-4 alkyl or C1-4 alkoxyl group or an acylamino group containing 1 to 4 carbon atoms in the acyl moiety; X stands for one of the groups of general formulae (IV), (V) or (VI), wherein R1 means hydrogen or a straight or branched chain C1-4 alkyl group of E and/or Z configuration as well as their salts. The compounds according to the invention show cytoprotective and gastric acid secretion-inhibiting effects; their toxicity is low.
(FR) Nouveaux composés ayant la formule générale (I) dans laquelle R représente de l'hydrogène ou de l'halogène ou un alkyle C1-4 ou un groupe alkoxy C1-4 ou un groupe acylamino contenant 1 à 4 atomes de carbone dans la moitié d'acyle; X représente un des groupes des formules générales (IV), (V) ou (VI) où R1 représente de l'hydrogène ou un groupe alkyle C1-4 à chaîne droite ou ramifiée de configuration E et/ou Z ainsi que leurs sels. D'après l'invention les composés présentent des effets cytoprotecteurs et suppresseurs de la sécrétion d'acides gastriques; leur toxicité est faible.
Designated States: JP, KR, US
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1019890701572