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1. (WO1989000156) PREPARATION OF ISOMERS OF MYO-INOSITOL DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000156 International Application No.: PCT/GB1988/000520
Publication Date: 12.01.1989 International Filing Date: 04.07.1988
Chapter 2 Demand Filed: 15.03.1989
IPC:
C07C 43/196 (2006.01) ,C07D 317/46 (2006.01) ,C07D 493/04 (2006.01) ,C07F 9/117 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
43
Ethers; Compounds having groups, groups or groups
02
Ethers
18
having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
196
containing hydroxy or O-metal groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
44
ortho- or peri-condensed with carbocyclic rings or ring systems
46
condensed with one six-membered ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
117
with cycloaliphatic alcohols
Applicants:
3i RESEARCH EXPLOITATION LIMITED [GB/GB]; 91 Waterloo Road London SE1 8XP, GB (AllExceptUS)
GIGG, Roy, Henry [GB/GB]; GB (UsOnly)
Inventors:
GIGG, Roy, Henry; GB
Agent:
BATCHELLOR, KIRK & EYLES; 2 Pear Tree Court Farringdon Road London EC1R 0DS, GB
Priority Data:
871555802.07.1987GB
Title (EN) PREPARATION OF ISOMERS OF MYO-INOSITOL DERIVATIVES
(FR) PREPARATION D'ISOMERES DE DERIVES DE MYO-INOSITOL
Abstract:
(EN) $i(Myo-)inositol derivatives which are useful as intermediates in the preparation of the phosphate esters have the general chemical formula: $i(Cy)C6H6(OH)n(OZ)m(OX)p, in which X is a mono- or divalent hydroxyl-protecting group, Z is a propenyl group, n is at least 1, m is at least 1, p is zero or an integer from 1 to 4 when X is monovalent or zero, 1 or 2 when X is divalent, and, n+m+p = 6. The hydroxyl-protecting group may be benzyl, $i(p)-methoxybenzyl, crotyl or isopropylidenyl and the compounds may be esterified with (-)-camphanic acid to resolve diastereoisomers. By using a selection of chemical reactions which have specific known effect on the starting materials it is possible to design derivatives of $i(myo-)inositol which have specific structures, providing useful intermediates for further reaction to insert substituents, for example, the phosphate and phosphorothiote ester groups, into specific positions in the cyclohexane ring of $i(myo-)inositol.
(FR) Dérivés de $i(myo-)inositol utiles à titre d'intermédiaires dans la préparation des esters de phosphate ayant la formule chimique générale: $i(Cy)C6H6(OH)n(OZ)m(OX)p, dans laquelle X représente un groupe protecteur hydroxylique mono ou bivalent, Z représente un groupe propénylique, n vaut au moins 1, m vaut au moins 1, p vaut zéro ou un entier allant de 1 à 4 lorsque X est monovalent ou représente zéro, 1 ou 2 lorsque X est bivalent, et n+m+p = 6. Le groupe protecteur hydroxylique peut être du benzyle, du méthoxybenzyle $i(p), du crotyle ou de l'isopropylidényle, et les composés peuvent être estérifiés avec de l'acide camphanique -(-) pour dissoudre les diastéréoisomères. Grâce à l'utilisation d'une sélection de réactions chimiques ayant des effets connus spécifiques sur les matières de départ, on peut créer des dérivés de $i(myo-)inositol ayant des structures spécifiques, offrant des intermédiaires utiles permettant une plus ample réaction afin d'introduire des substituants, par exemple, les groupes d'esters de phosphate et de phosphorothiote, dans des positions spécifiques dans l'anneau de cyclohexane de $i(myo-)inositol.
Designated States: JP, US
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0376955EP0579957DE000003886945