Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO1989000051) FIBRIN-BINDING COMPOUND AND METHOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000051 International Application No.: PCT/US1988/002276
Publication Date: 12.01.1989 International Filing Date: 01.07.1988
IPC:
A61K 49/08 (2006.01) ,A61K 51/08 (2006.01) ,G01N 33/86 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86
involving blood coagulating time
Applicants:
CYTRX BIOPOOL LTD. [US/US]; 150 Technology Parkway Technology Park/Atlanta Norcross, GA 30092, US
Inventors:
RANBY, Mats, Gustaf; SE
WIMAN, Tor-Bjorn; SE
Agent:
GRAHAM, Jamie, L. @; CytRx Biopool Ltd. 150 Technology Parkway Technology Park/Atlanta Norcross, GA 30092, US
Priority Data:
070,71007.07.1987US
Title (EN) FIBRIN-BINDING COMPOUND AND METHOD
(FR) COMPOSE SE LIANT A LA FIBRINE ET PROCEDE
Abstract:
(EN) The present invention relates to a method and compound that is useful for targeting deposits of fibrin. The present invention is a compound that can be acted upon by the enzyme Factor XIIIa so that the compound is covalently bound to fibrin deposits in the body. The compound can be used to prepare diagnostic or therapeutic reagents that will then be bound to fibrin deposits. This can facilitate detection or treatment of the fibrin deposit or disease process anatomically associated with fibrin. The compound can be attached to a fibrinolytic protein by either chemical or recombinant DNA methods thereby making the protein specific for fibrin.
(FR) Procédé et composé utiles afin de cibler des dépôts de fibrine. La présente invention est un composé pouvant subir l'action du Facteur enzymatique XIIIa, de telle sorte que le composé soit lié par covalence aux dépôts de fibrine se trouvant dans le corps. Le composé peut être utilisé pour préparer des réactifs de diagnostic ou thérapeutiques qui seront ensuite liés à des dépôts de fibrine. Cela peut faciliter la détection ou le traitement du dépôt de fibrine ou du processus pathologique anatomiquement associé à la fibrine. Le composé peut être fixé à une protéine fibrinolytique par des procédés soit chimiques soit d'ADN recombinant, rendant ainsi la protéine spécifique contre la fibrine.
Designated States: AU, BB, BG, BR, DK, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, RO, SD, SU
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0325639AU1988022587