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1. (WO1989000045) PELLETS WITH ENZYMATICALLY CONTROLLED DRUG RELEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1989/000045 International Application No.: PCT/US1988/002131
Publication Date: 12.01.1989 International Filing Date: 23.06.1988
Chapter 2 Demand Filed: 16.02.1989
IPC:
A61K 9/16 (2006.01) ,A61K 9/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
Applicants:
RIKER LABORATORIES, INCORPORATED [US/US]; Building 225-1N-07, 3M Center Saint Paul, MN 55144-1000, US
Inventors:
ZERBE, Horst-Georg; DE
BECKER, Jorn, Ullrich; DE
Agent:
SPRAGUE, Robert, W. @; Minnesota Mining and Manufacturing Company P.O. Box 33427 Saint Paul, MN 55133-3427, US
BAILLE, Iain, C.; Ladas & Parry Isartorplatz 5 D-8000 München 2, DE
Priority Data:
P 37 21 574.430.06.1987DE
Title (EN) PELLETS WITH ENZYMATICALLY CONTROLLED DRUG RELEASE
(FR) COMPRIMES A LIBERATION DE MEDICAMENTS REGULEE DE MANIERE ENZYMATIQUE
Abstract:
(EN) Pharmaceutical compositions in pellet form with enzymatically controlled release of the pharmaceutical substance are described which comprise a core and an envelope layer surrounding said core. The core contains the pharmaceutical substance, an enzyme and a substrate for the enzyme. The envelope layer contains a water-insoluble film-forming macromolecular substance and a water-soluble pore former.
(FR) Sont décrites des compositions pharmaceutiques sous forme de comprimés à libération régulée de manière enzymatique de la substance pharmaceutique, comprenant un noyau et un couche enveloppant ledit noyau. Le noyau contient la substance pharmaceutique, une enzyme et un substrat destiné à l'enzyme. La couche d'enveloppe contient une substance macromoléculaire formant une couche mince insoluble dans l'eau ainsi qu'un élément formant des pores solubles dans l'eau.
Designated States: AU, DK, JP, NO
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0370049JPH02504145AU1988021245