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Machine translation
1. (WO1988006439) PHOSPHOLIPASE A¿2?-RESISTANT LIPOSOMES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1988/006439    International Application No.:    PCT/US1988/000508
Publication Date: 07.09.1988 International Filing Date: 19.02.1988
Chapter 2 Demand Filed:    25.10.1988    
IPC:
A61K 9/127 (2006.01)
Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA [US/US]; Morrill Hall, 100 Church Street SE, Minneapolis, MN 55455 (US)
Inventors: BAUMANN, Wolfgang, J.; (US)
Agent: FREED, Robert, C.; Merchant, Gould, Smith, Edell, Welter & Schmidt, 1600 Midwest Plaza Building, Minneapolis, MN 55402 (US).
WIKLUND, Erik @; Awapatent AB, Box 5117, S-200 71 Malmö (SE)
Priority Data:
017,369 24.02.1987 US
Title (EN) PHOSPHOLIPASE A¿2?-RESISTANT LIPOSOMES
(FR) LIPOSOMES RESISTANTS A LA PHOSPHOLIPASE A¿2?
Abstract: front page image
(EN)A method to inhibit phospholipase A¿2?-type hydrolytic degradation of liposome membranes is disclosed comprising forming a liposome having a bilayer membrane comprising (i) between about 67.5-85 mol-% of a phospholipid of formula (I), and (ii) between about 15.0-32.5 mol-% of a lysophospholipid of formula (II), wherein R¿2?, R¿1? and R¿3? are individually (C¿10?-C¿30?) alkanoyl groups including from about 0-4 double bonds.
(FR)Un procédé de prévention de la dégradation hydrolytique de membranes de liposomes du type provoquée par la phospholipase A¿2? comprend la formation d'un liposome ayant une membrane à double couche qui comprend (i) entre 67,5 et 85 moles % environ d'un phospholipide ayant la formule (I) et (ii) entre 15,0 et 32,5 moles % environ d'un lysophospholipide ayant la formule (II), dans lesquelles R¿1?, R¿2? et R¿3? représentent individuellement des groupes (C¿10?-C¿30?)alkanoyl comprenant entre 0 et 4 liaisons doubles.
Designated States: JP.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)