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1. WO1988001511 - SUCCINYLATED INTERLEUKIN-2 FOR PHARMACEUTICAL COMPOSITIONS

Publication Number WO/1988/001511
Publication Date 10.03.1988
International Application No. PCT/US1987/002132
International Filing Date 25.08.1987
IPC
C07K 14/55 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
55IL-2
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
55IL-2
Applicants
  • CETUS CORPORATION [US]/[US]
Inventors
  • KATRE, Nandini
  • KNAUF, Michael, J.
Agents
  • HALLUIN, Albert, P.
Priority Data
903,66804.09.1986US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUCCINYLATED INTERLEUKIN-2 FOR PHARMACEUTICAL COMPOSITIONS
(FR) INTERLEUKINE-2 SUCCINYLEE POUR COMPOSITIONS PHARMACEUTIQUES
Abstract
(EN)
A pharmaceutical composition is prepared wherein biologically active conjugated interleukin-2 is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated IL-2, which is not water soluble at pH 6-8 without such solubilizing agent, is selectively conjugated to one or more succinyl groups by reaction with succinic anhydride.
(FR)
Dans la préparation d'une composition pharmaceutique, l'interleukine-2 conjuguée biologiquement active est dissoute dans un milieu porteur aqueux en l'absence d'un agent de solubilisation. L'IL-2 non conjuguée, qui n'est pas hydrosoluble à un pH compris entre 6 et 8 sans un tel agent de solubilisation, est conjuguée sélectivement avec un ou plusieurs groupes succinyle par réaction avec de l'anhydride succinique.
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